PMID: 1206500Dec 1, 1975Paper

Bioequivalency of doxycycline products

Journal of Pharmaceutical Sciences
E J AntalJ L Colaizzi

Abstract

The bioavailability of three different brands and three different dosage forms of doxycycline was studied in normal subjects. Single doses, equivalent to 200 mg of doxycycline, were administered to six subjects in a crossover design as the innovator's intravenous solution given orally (Treatment A), the innovator's capsule product (Treatment B), a noninnovator's capsule product (Treatment C), the innovator's oral suspension product (Treatment D), and a second noninnovator's capsule product (Treatment E). All dosage forms contained doxycycline as the hyclate, except the suspension which contained the nonhyclate form. Serum levels were determined periodically over 48 hr, and cumulative urinary excretion was measured concurrently over a 120-hr collection period. No statistically significant differences were observed in any in vivo indicator of bioequivalence when the three capsule products were compared. Consequently, they were judged to be bioequivalent. When these capsule products were compared to the oral solution, no statistically significant differences were observed. However, when the capsules and the suspension were compared, statistically significant differences were found in the rate of absorption. In vitro dissolution te...Continue Reading

References

May 19, 1969·JAMA : the Journal of the American Medical Association·G W Brice, H F Hammer

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Citations

Mar 11, 2011·Isotopes in Environmental and Health Studies·Peter Krumbiegel
Oct 3, 2009·Journal of Pharmaceutical Sciences·E JantratidD M Barends
Jul 1, 1996·Journal of Pharmaceutical Sciences·J E PolliG L Amidon

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