Bioevaluation of plasma polymerized films in skeletal muscle

Journal of Biomedical Materials Research
M F NicholsK G Mayhan

Abstract

Plasma polymerized ethylene (PPE), styrene (PPS), and chlorotrifluoroethylene (PPCTFE) were synthesized by exposing the monomeric gases to an inductively coupled radio frequency "glow-discharge" field. The polymer films were deposited on poly(dimethyl) siloxane (medical grade Silastic), which was then surgically implanted in rat paravertebral muscle for periods up to 84 weeks. The biocompatibility of the plasma deposited films and uncoated Silastic was evaluated by qualitative (graded inflammatory cell response) and quantitative (connnective tissue capsule thickness) techniques as a function of time. The morphological features of the connective tissue capsule and the plasma polymerized films were examined by SEM after 75 weeks of implantation. Results showed that the acute inflammatory cell migration around PPS and PPCTFE was at a maximum in 2 weeks, decaying to control levels in 4 to 8 weeks. The PPE response was judged as less than the control response up to 4 weeks. After 8 weeks no qualitative difference could be detected between the plasma polymerized films and Silastic. On the other hand, a quantifiable change in fibrous capsule response as a function of time and material was noted until 24 weeks. From these data we concl...Continue Reading

References

Jan 27, 1975·Annals of the New York Academy of Sciences·E B SandbornM Bendayan
Jan 1, 1976·Biomaterials, Medical Devices, and Artificial Organs·R E Wilsnack
Nov 1, 1975·Journal of Biomedical Materials Research·H YasudaJ Carver
May 1, 1976·Journal of Biomedical Materials Research·B F MatlagaT N Salthouse
Mar 1, 1972·Journal of Biomedical Materials Research·T N Salthouse, D A Willigan
Jan 1, 1974·Biomaterials, Medical Devices, and Artificial Organs·J L SandrikE H Greener
Sep 1, 1974·Journal of Biomedical Materials Research·D L ColemanJ D Andrade
Jan 1, 1974·Journal of Biomedical Materials Research·I R TorantoW B Nickell
Jan 1, 1973·Journal of Biomedical Materials Research·J E TurnerJ Autian
Mar 1, 1970·Journal of Biomedical Materials Research·N K WoodR J Oglesby
Mar 1, 1967·Journal of Biomedical Materials Research·P G LaingE S Hodge
Mar 1, 1968·Journal of Biomedical Materials Research·E J KaminskiJ Sandrik
Apr 1, 1965·Medical electronics & biological engineering·S BRALEY

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Citations

Aug 1, 1996·Journal of Endovascular Surgery : the Official Journal of the International Society for Endovascular Surgery·A B FontaineD G Spigos

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