Biofilm Cohesive Strength as a Basis for Biofilm Recalcitrance: Are Bacterial Biofilms Overdesigned?

Microbiology Insights
Srijan AggarwalRaymond M Hozalski

Abstract

Bacterial biofilms are highly resistant to common antibacterial treatments, and several physiological explanations have been offered to explain the recalcitrant nature of bacterial biofilms. Herein, a biophysical aspect of biofilm recalcitrance is being reported on. While engineering structures are often overdesigned with a factor of safety (FOS) usually under 10, experimental measurements of biofilm cohesive strength suggest that the FOS is on the order of thousands. In other words, bacterial biofilms appear to be designed to withstand extreme forces rather than typical or average loads. In scenarios requiring the removal or control of unwanted biofilms, this emphasizes the importance of considering strategies for structurally weakening the biofilms in conjunction with bacterial inactivation.

References

May 21, 1999·Science·J W CostertonE P Greenberg
Jul 21, 2001·Lancet·P S Stewart, J W Costerton
Feb 23, 2002·Science·Cynthia B WhitchurchJohn S Mattick
Apr 18, 2002·Antimicrobial Agents and Chemotherapy·C CampanacC Roques
Dec 17, 2002·Journal of Industrial Microbiology & Biotechnology·P StoodleyI Klapper
Mar 26, 2003·Journal of Applied Physiology·Gianluca NucciKenneth Lutchen
Mar 30, 2004·Journal of Biomechanics·A S Green
Sep 28, 2004·Physical Review Letters·T ShawP Stoodley
May 26, 2005·Colloids and Surfaces. B, Biointerfaces·M J ChenT R Bott
Aug 11, 2006·Water Science and Technology : a Journal of the International Association on Water Pollution Research·J R LiuS N Liss
Dec 15, 2006·Water Science and Technology : a Journal of the International Association on Water Pollution Research·H NagaokaM Kobayashi
Dec 17, 2008·Journal of Bacteriology·David G Davies, Cláudia N H Marques
Jul 23, 2009·Journal of the American Chemical Society·Steven A RogersChristian Melander
May 31, 2012·Critical Reviews in Biotechnology·Markus BölRainer Krull
Jul 24, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Donavon J HessCarol L Wells
Jan 1, 2014·Pathogens and Disease·Philip S Stewart

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