Biofilm formation by Neisseria meningitidis

Infection and Immunity
Kyungcheol YiIgor Stojiljkovic

Abstract

Biofilm formation by the human pathogen Neisseria meningitidis was analyzed. Biofilm-forming meningococcal strains were identified and quantitated by crystal violet staining. Laser scanning confocal microscopy of the meningococcal biofilm revealed variable layers up to 90 microm in thickness. A total of 39 meningococcal isolates were studied; 23 were nasopharyngeal-carriage isolates, and 16 were invasive-disease isolates. Thirty percent of carriage isolates and 12.5% of invasive-disease isolates formed biofilms proficiently on a polystyrene surface. Generally, the strains that formed biofilms showed high-level cell surface hydrophobicity, characteristic of strains lacking a capsule. The inhibitory role of capsule in biofilm formation was further confirmed by comparing the biofilm-forming capabilities of a serogroup B wild-type strain of a disease-associated isolate to those of its capsule-deficient mutant (ctrA). Some strains of meningococci form biofilms, and this process is likely important in menigococcal colonization.

References

Jul 1, 1992·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·A E KhouryJ W Costerton
Sep 1, 1995·Journal of Dental Research·A LeonhardtG Dahlén
Apr 1, 1994·Journal of Bacteriology·J W CostertonG James
Jan 1, 1995·Annual Review of Microbiology·J W CostertonH M Lappin-Scott
Mar 1, 1996·Nutrition·K A Adal, B M Farr
Jun 1, 1997·Infectious Disease Clinics of North America·L K Archibald, R P Gaynes
Feb 26, 1999·Trends in Microbiology·C DehioT F Meyer
May 21, 1999·Science·J W CostertonE P Greenberg
Nov 17, 1999·Molecular Microbiology·P I Watnick, R Kolter
Oct 6, 2000·Annual Review of Microbiology·G O'TooleR Kolter
Oct 29, 2000·Journal of Applied Microbiology·K A Saunders, J Greenman
May 22, 2001·Molecular Microbiology·A R Richardson, I Stojiljkovic
Apr 27, 2002·Applied and Environmental Microbiology·Bjarke B ChristensenSøren Molin
Jun 29, 2002·The Journal of Infectious Diseases·Scott E KellermanUNKNOWN Georgia Emerging Infections Program
Sep 27, 2002·Applied and Environmental Microbiology·Jeffrey B Kaplan, Daniel H Fine
Mar 5, 2003·Epidemiology and Infection·F SadlerR Borrow
Mar 26, 2003·Infection and Immunity·Kyungcheol YiIgor Stojiljkovic
May 2, 2003·The Journal of Infectious Diseases·Jennifer M Dolan-LivengoodDavid S Stephens
Jun 6, 2003·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Catherine Harrison-BalestraPatricia M Mertz
Jun 7, 2003·Molecular Microbiology·Mikkel KlausenTim Tolker-Nielsen
Jul 5, 2003·Science·Gregory G AndersonScott J Hultgren
Jul 10, 2003·Current Opinion in Biotechnology·Søren Molin, Tim Tolker-Nielsen

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Citations

Apr 9, 2010·Medical Microbiology and Immunology·Martin Lappann, Ulrich Vogel
May 4, 2011·The Journal of Microbiology·Christin N McQueary, Luis A Actis
Jul 3, 2013·Infection and Immunity·Anne JametXavier Nassif
Mar 24, 2005·Infection and Immunity·L L GreinerM A Apicella
Nov 21, 2007·Canadian Journal of Microbiology·Myron T La DucKasthuri Venkateswaran
Jun 6, 2009·Future Microbiology·R Brock Neil, Michael A Apicella
Aug 6, 2011·Trends in Microbiology·Kaushali TrivediRachel M Exley
Mar 2, 2016·Scientific Reports·Senthil V BhoopalanDaniel C Stein
Dec 31, 2008·Microbes and Infection·R Brock NeilMichael A Apicella
Mar 17, 2007·Microbial Pathogenesis·Kiyonobu HonmaAshu Sharma
Jun 25, 2009·Environmental Microbiology·Mirian DomenechMiriam Moscoso
Jul 26, 2014·Environmental Microbiology·Jesús ArenasJan Tommassen
Feb 26, 2010·Molecular Microbiology·Martin LappannUlrich Vogel
May 24, 2015·Biochimica Et Biophysica Acta·Yih-Ling Tzeng, David S Stephens
Feb 1, 2006·FEMS Microbiology Letters·Marjan W van der Woude
Oct 8, 2016·Trends in Microbiology·Jesús Arenas, Jan Tommassen
Oct 8, 2016·Molecular Oral Microbiology·J B KaplanN V Balashova
Apr 9, 2017·BMC Genomics·Biju Joseph AmpattuChristoph Schoen
Jan 1, 2013·Biology·Miao-Chiu Hung, Myron Christodoulides
Mar 5, 2017·Applied and Environmental Microbiology·MaFeng LiuAnChun Cheng
Aug 9, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maike G MüllerGregory R Moe
Apr 7, 2017·Frontiers in Microbiology·Jesús Pérez-OrtegaJesús Arenas
Sep 11, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bayarchimeg MashbatVanessa Sancho-Shimizu
Dec 7, 2016·Frontiers in Cellular and Infection Microbiology·Jesús ArenasJan Tommassen
Jul 18, 2015·Microbiology Spectrum·Dominique H LimoliDaniel J Wozniak

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