Biofilm inhibition and pathogenicity attenuation in bacteria by Proteus mirabilis

Royal Society Open Science
Shichen YuZhonghua Cai

Abstract

Biofilms play an important role in the antibiotic resistance of encased bacteria, and biofilm formation is regulated by quorum sensing (QS). Inhibiting the QS system may, therefore, degrade the integrity of a biofilm and expose the bacterial pathogens within it to the deleterious effects of molecules such as antibiotics. Moreover, the use of QS inhibitors (QSIs) may provide a novel approach for treating bacterial infections of aquacultures. In the present study, the bacterium Proteus mirabilis was identified as a potential producer of QSIs. Varying concentrations (0.1-1.1%) of filtrates prepared from the culture of P. mirabilis inhibited biofilm formation by the pathogens Pseudomonas aeruginosa, Vibrio harveyi and Staphylococcus aureus by as much as 58.9%, 41.5% and 41.9%, respectively. These filtrates as well as the crude aqueous extracts prepared from them increased the sensitivities of pathogens to the inhibitory effects of kanamycin. The filtrates also showed pathogenicity attenuation potential in P. aeruginosa by decreasing the production of virulence factors. Moreover, the filtrates did not influence the planktonic growth of these pathogens. The results indicate that P. mirabilis may act as a non-specific (or broad-spectr...Continue Reading

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Citations

Nov 19, 2019·Frontiers in Microbiology·Paweł Krzyżek
Sep 11, 2020·International Journal of Microbiology·Gedif Meseret Abebe
Dec 29, 2020·Critical Reviews in Microbiology·Wen YinJin He

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Datasets Mentioned

BETA
NR
043997.1

Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

CAP3
BLAST
SPSS
Statistical Package for the Social Sciences ( SPSS )

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