Biofilm is a Major Virulence Determinant in Bacterial Colonization of Chronic Skin Ulcers Independently from the Multidrug Resistant Phenotype

International Journal of Molecular Sciences
Enea Gino Di DomenicoFabrizio Ensoli

Abstract

Bacterial biofilm is a major factor in delayed wound healing and high levels of biofilm production have been repeatedly described in multidrug resistant organisms (MDROs). Nevertheless, a quantitative correlation between biofilm production and the profile of antimicrobial drug resistance in delayed wound healing remains to be determined. Microbial identification, antibiotic susceptibility and biofilm production were assessed in 135 clinical isolates from 87 patients. Gram-negative bacteria were the most represented microorganisms (60.8%) with MDROs accounting for 31.8% of the total isolates. Assessment of biofilm production revealed that 80% of the strains were able to form biofilm. A comparable level of biofilm production was found with both MDRO and not-MDRO with no significant differences between groups. All the methicillin-resistantStaphylococcus aureus(MRSA) and 80% ofPseudomonas aeruginosaMDR strains were found as moderate/high biofilm producers. Conversely, less than 17% ofKlebsiella pneumoniaeextended-spectrum beta-lactamase (ESBL),Escherichia coli-ESBL andAcinetobacter baumanniiwere moderate/high biofilm producers. Notably, those strains classified as non-biofilm producers, were always associated with biofilm producer ...Continue Reading

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Citations

Sep 1, 2017·International Journal of Molecular Sciences·Enea Gino Di DomenicoFabrizio Ensoli
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Methods Mentioned

BETA
electron
biopsies

Software Mentioned

SPSS

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