Biofilm production and antibiotic susceptibility of Staphylococcus epidermidis strains from Hidradenitis Suppurativa lesions

Journal of the European Academy of Dermatology and Venereology : JEADV
C B ArdonGregor B E Jemec

Abstract

An aberrant interaction between commensal skin bacteria and the host skin immune system is considered important in the pathogenesis of hidradenitis suppurativa (HS). In this study, we investigated the antibiotic susceptibility and biofilm-forming capabilities of S. epidermidis strains isolated from HS patients. Skin biopsies were taken from active HS lesions such as inflammatory nodules and/or sinuses and non-involved skin from 26 patients and cultured under optimal microbiological conditions for 24 h. Planktonic growth, biofilm production, antibiotic susceptibility and biofilm eradication by clindamycin, doxycycline, rifampicin and tetracycline were tested including a laboratory control strain of S. epidermidis for reference. Staphylococcus epidermidis was cultured in 16 of 26 HS patients (62%). In total 27 different S. epidermidis isolates were identified; 16 (59%) from non-involved skin and 11 (41%) from HS lesions. All bacterial strains showed planktonic growth. Twenty-four of 27 (89%) isolates were strong biofilm producers in vitro. The biofilm-forming capability varied amongst the strains from non-involved skin and lesional skin. Twenty-four strains had an intermediate to resistant antibiotic susceptibility to clindamycin...Continue Reading

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Citations

Feb 26, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·C B ArdonH Jenssen
Jul 3, 2020·Experimental Dermatology·Samuel C WilliamsJames G Krueger
May 21, 2019·Frontiers in Immunology·Paola M TricaricoSergio Crovella
Nov 28, 2020·Dermatology and Therapy·Kirsty J L Wark, Geoffrey D Cains
Oct 12, 2019·Journal of the American Academy of Dermatology·Samantha R GoldburgMichael J Payette
Dec 18, 2020·European Journal of Hospital Pharmacy. Science and Practice·Jaime Cordero-RamosMiguel Ángel Calleja-Hernández
May 22, 2021·Experimental Dermatology·Stephanie L SchellAmanda M Nelson

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