Biofilm-related infections of cerebrospinal fluid shunts

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
C A FuxR H Veeh

Abstract

Cerebrospinal fluid (CSF) shunts carry a high risk of complications. Infections represent a major cause of shunt failure. Diagnosis and therapy of such infections are complicated by the formation of bacterial biofilms attached to shunt surfaces. This study correlated the pathophysiology and clinical course of biofilm infections with microscopical findings on the respective shunts. Surface irregularities, an important risk-factor for shunt colonisation with bacteria, were found to increase over time because of silicone degradation. Scanning electron-microscopy (SEM) documented residual biological material (dead biofilm), which can further promote extant bacterial adhesion, on newly manufactured shunts. Clinical course and SEM both documented bacterial dissemination against CSF flow and the monodirectional valve. In all cases, biofilms grew on both the inner and outer surfaces of the shunts. Microscopy and conventional culture detected all bacterial shunt infections. Analyses of 16S rDNA sequences using conserved primers identified bacteria in only one of three cases, probably because of previous formalin fixation of the samples.

References

Nov 1, 1990·The Journal of Hospital Infection·L Martínez-MartínezE J Perea
May 1, 1994·British Journal of Anaesthesia·S E TebbsT S Elliott
Jan 1, 1995·Pediatric Neurosurgery·C P Bondurant, D F Jimenez
Feb 5, 1998·JAMA : the Journal of the American Medical Association·M G RaynerG D Ehrlich
Apr 29, 1998·Antimicrobial Agents and Chemotherapy·S SchwankJ Blaser
Aug 7, 1998·Pediatric Neurosurgery·W PumbergerW Geissler
Apr 2, 1999·Clinical Orthopaedics and Related Research·D P HoeffelK L Garvin
May 21, 1999·Science·J W CostertonE P Greenberg
Feb 22, 2000·Pediatric Neurosurgery·C BairdT Pittman
Apr 4, 2000·Microbiology·K D XuP S Stewart
Aug 16, 2001·European Journal of Nuclear Medicine·M HidakaY Suzuki
Sep 25, 2001·The Journal of Pathology·F LewisP Quirke
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M C WeijmerP M ter Wee
Nov 1, 2002·Journal of Clinical Microbiology·Kaisu Rantakokko-Jalava, Jari Jalava
Mar 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew J McGirtDaniel J Sexton
May 14, 2003·Archives of Pathology & Laboratory Medicine·Ben MargolisSerhan Alkan
Jun 17, 2003·Journal of Medical Microbiology·Susanna PajuFrank A Scannapieco
Jul 12, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Philipp Peter BosshardMartin Altwegg
Sep 11, 2003·Clinical Orthopaedics and Related Research·Ivan S TarkinKevin L Garvin

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Citations

May 28, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P RamírezJ Bonastre
May 15, 2008·Journal of the Royal Society, Interface·Yinghui Zhong, Ravi V Bellamkonda
Mar 21, 2012·Antimicrobial Agents and Chemotherapy·Roger BaystonWaheed Ashraf
May 17, 2014·Surgical Infections·Sandeep KathjuPaul Stoodley
Apr 21, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Adem YilmazYunus Aydin
Mar 8, 2016·Clinical Neurology and Neurosurgery·Wael Mohamed Mohamed Moussa, Mohamed Abbas Aly Mohamed
Jun 4, 2014·The Journal of Obstetrics and Gynaecology Research·Mohamed Abdel-HafeezAhmed Elnaggar
Dec 17, 2014·International Journal of Oral Science·Hong WuZhi-Jun Song
Jun 19, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·N T StevensH Humphreys
Jun 25, 2016·Antibiotics·Tianyan SongSun Nyunt Wai
Jan 28, 2017·Angewandte Chemie·Michael KatherSabine Neuss
Sep 7, 2014·Scottish Medical Journal·Emily MullanRobert Carachi
Aug 24, 2018·Journal of Clinical Microbiology·Ryan M MartinChristopher R Polage
Jan 11, 2019·Journal of Neuroinflammation·Gwenn L SkarJessica N Snowden
Feb 28, 2019·Chembiochem : a European Journal of Chemical Biology·Robert W HuigensHongfen Yang
Jul 16, 2019·Clinical Neurology and Neurosurgery·Bujung HongJoachim K Krauss
Jun 15, 2021·Frontiers in Microbiology·Donald C HallJarosław E Król
Mar 16, 2020·ACS Applied Bio Materials·Kaitlyn L KearnsMartha E Grady

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