Biofluid Proteomics and Biomarkers in Traumatic Brain Injury

Methods in Molecular Biology
Safa AzarStefania Mondello

Abstract

Traumatic brain injury (TBI) is an injury to the brain caused by an external mechanical force, affecting millions of people worldwide. The disease course and prognosis are often unpredictable, and it can be challenging to determine an early diagnosis in case of mild injury as well as to accurately phenotype the injury. There is currently no cure for TBI-drugs having failed repeatedly in clinical trials-but an intense effort has been put to identify effective neuroprotective treatment. The detection of novel biomarkers, to understand more of the disease mechanism, facilitates early diagnosis, predicts disease progression, and develops molecularly targeted therapies that would be of high clinical interest. Over the last decade, there has been an increasing effort and initiative toward finding TBI-specific biomarker candidates. One promising strategy has been to use state-of-the-art neuroproteomics approaches to assess clinical biofluids and compare the cerebrospinal fluid (CSF) and blood proteome between TBI and control patients or between different subgroups of TBI. In this chapter, we summarize and discuss the status of biofluid proteomics in TBI, with a particular focus on the latest findings.

Citations

Sep 25, 2019·Journal of Experimental Neuroscience·Daniel W BrydenSidney R Hinds
Sep 16, 2017·Frontiers in Neurology·Ari ErcoleElisa R Zanier
Aug 1, 2020·Frontiers in Neurology·Stefania MondelloJessica M Gill
Jul 6, 2019·Spinal Cord·Brian K KwonKevin K Wang
Jul 3, 2018·Frontiers in Neurology·Valentina Di PietroAntonio Belli
Apr 10, 2019·Journal of Intensive Care Medicine·Cristina Sánchez CarabiasAlfonso Lagares
Mar 12, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Dana SlavoacaPieter Vos
Jan 7, 2021·Neurocritical Care·Maryam EdalatfarMahdi Sharif-Alhoseini
Jul 3, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiao-Qiao DongLi Jiang
Sep 10, 2018·Neuropharmacology·Kathryn ToffoloDavid Poulsen
Jul 9, 2021·Nature and Science of Sleep·Stefania MondelloRaffaele Ferri

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