Biofunctionalization of selective laser melted porous titanium using silver and zinc nanoparticles to prevent infections by antibiotic-resistant bacteria.

Acta Biomaterialia
I A J van HengelA A Zadpoor

Abstract

Antibiotic-resistant bacteria are frequently involved in implant-associated infections (IAIs), making the treatment of these infections even more challenging. Therefore, multifunctional implant surfaces that simultaneously possess antibacterial activity and induce osseointegration are highly desired in order to prevent IAIs. The incorporation of multiple inorganic antibacterial agents onto the implant surface may aid in generating synergistic antibacterial behavior against a wide microbial spectrum while reducing the occurrence of bacterial resistance. In this study, porous titanium implants synthesized by selective laser melting (SLM) were biofunctionalized with plasma electrolytic oxidation (PEO) using electrolytes based on Ca/P species as well as silver and zinc nanoparticles in ratios from 0 to 100% that were tightly embedded into the growing titanium oxide layer. After the surface bio-functionalization process, silver and zinc ions were released from the implant surfaces for at least 28 days resulting in antibacterial leaching activity against methicillin-resistant Staphylococcus aureus (MRSA). Furthermore, the biofunctionalized implants generated reactive oxygen species, thereby contributing to antibacterial contact-killi...Continue Reading

Citations

Nov 27, 2020·Nanomaterials·Oana GherasimAlexandru Mihai Grumezescu
Mar 2, 2021·The Bone & Joint Journal·Anna Diez-Escudero, Nils P Hailer
Mar 20, 2021·ACS Biomaterials Science & Engineering·Anna DonnadioMorena Nocchetti
Apr 9, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Maryam MolaeiArash Fattah-Alhosseini
May 1, 2021·International Journal of Molecular Sciences·Ingmar A J van HengelAmir A Zadpoor
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·I A J van HengelA A Zadpoor
Jun 25, 2021·Advanced Science·Donghui WangXuanyong Liu
Jul 31, 2021·Journal of Biomaterials Science. Polymer Edition·Zhiqiang Ma, Zhongyi Dong

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