Biofunctionalization of titanium implants with a biomimetic active peptide (P-15) promotes early osseointegration

Clinical Oral Implants Research
R LutzK A Schlegel

Abstract

The early stages of peri-implant bone formation play an essential role in the osseointegration and long-term success of dental implants. By incorporating bioactive coatings, this biofunctionalization of implant surfaces may enhance the attachment of the implant to the surrounding bone and stimulate bone regeneration. To demonstrate faster osseointegration, the surfaces of dental implants were grit-blasted and acid-etched. They were then coated with hydroxyapatite (HA) and experimental implants were further coated with a biomimetic active peptide (P-15) in one of two concentrations. These biofunctionalized samples and controls with no peptide were placed in the forehead region of 12 adult pigs. Six animals were evaluated for a period of 14 or 30 days. Histomorphometric analysis demonstrated that the implants with the high concentration of P-15 had significantly higher percentage of bone-to-implant contact (BIC) at 14 (P=0.018) and 30 (P=0.015) days compared with the other groups. Both concentrations of P-15 showed increased peri-implant bone density compared to the control group at 30 days. Biofunctionalization of the implant surface with a biomimetic active peptide leads to significantly increased BIC rates at 14 and 30 days an...Continue Reading

References

Jan 1, 1996·Annual Review of Cell and Developmental Biology·E Ruoslahti
Dec 30, 1999·Biomaterials·D M FerrisR F Valentini
Aug 14, 2001·Journal of Dental Research·G B SchneiderC Stanford
Feb 26, 2003·Journal of Biomedical Materials Research. Part a·S RösslerH Worch
Mar 15, 2003·Nature Reviews. Cancer·John D Hood, David A Cheresh
Oct 25, 2003·Biochemical and Biophysical Research Communications·Hieu NguyenSong Li
Apr 2, 2004·Nature·Robert Langer, David A Tirrell
Sep 15, 2004·Tissue Engineering·Xuebin B YangRichard O C Oreffo
Feb 22, 2005·Biomaterials·Monica DettinPier Paolo Parnigotto
Mar 2, 2005·Biochemical and Biophysical Research Communications·Michael ThorwarthKarl Andreas Schlegel
Apr 21, 2005·Journal of Dental Research·A J García, C D Reyes
May 10, 2005·Biomaterials·Michael ThorwarthKarl Andreas Schlegel
May 11, 2005·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Gösta Granström
Jul 13, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Karl Andreas SchlegelJörg Wiltfang
Aug 15, 2006·Dental Materials : Official Publication of the Academy of Dental Materials·L Le GuéhennecY Amouriq
Nov 10, 2006·Clinical Oral Implants Research·Karl Andreas SchlegelStephan Rupprecht
Feb 3, 2007·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Rajendra Bhatnagar, Song Li
Mar 6, 2007·European Cells & Materials·A I PearceS G Pearce
Jul 26, 2007·Journal of Oral Rehabilitation·C ScullyP D Dios
Dec 14, 2007·Biomaterials·Wenguang LiuFengfu Li
Apr 22, 2008·Clinical Oral Implants Research·Rainer LutzKarl Andreas Schlegel
Apr 29, 2008·The International Journal of Oral & Maxillofacial Implants·Perry R Klokkevold, Thomas J Han
Sep 1, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Karl Andreas SchlegelRainer Lutz

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Citations

Apr 3, 2012·Advanced Drug Delivery Reviews·Román A PérezHae-Won Kim
Oct 26, 2010·Oral and Maxillofacial Surgery·Silvio TaschieriMassimo Del Fabbro
May 9, 2015·International Journal of Molecular Sciences·Mu-Hyon KimJung-Bo Huh
Jun 20, 2012·Advanced Drug Delivery Reviews·Kazuhiro AokiKeiichi Ohya
Dec 1, 2015·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·J NonhoffK A Schlegel
Nov 25, 2011·Clinical Oral Implants Research·K A SchlegelC von Wilmowsky
Aug 19, 2014·Journal of Clinical Periodontology·Tobias MoestKarl Andreas Schlegel
Oct 10, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Paulo G CoelhoRyo Jimbo
Sep 5, 2013·The Journal of Oral Implantology·Sergio Alexandre GehrkePaulo Guilherme Coelho
Oct 8, 2015·Tissue Engineering. Part C, Methods·Stefano SivolellaBarbara Zavan
Jun 5, 2015·Clinical Implant Dentistry and Related Research·Sergio Alexandre Gehrke, Ulisses Tavares da Silva Neto
Mar 29, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Cornelia Katharina MuellerStefan Schultze-Mosgau
Oct 18, 2016·International Journal of Implant Dentistry·Oscar G BodelónMaría Cristina García Alonso
Aug 30, 2018·Journal of Biomaterials Science. Polymer Edition·Min LaiZiyang Jin
Feb 23, 2019·Journal of Biomedical Materials Research. Part a·Jie LiaoXiaoming Li
Mar 7, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kenneth R St John
Jul 3, 2020·Journal of Clinical Medicine·Nansi López-ValverdeAntonio López-Valverde
Oct 31, 2018·Clinical Oral Investigations·Sándor FarkasdiGábor Varga
Nov 13, 2018·International Journal of Dentistry·Helder H M MenezesElizabeth F Martinez
Jun 1, 2018·BioMed Research International·Sergio Alexandre GehrkeJamil Awad Shibli
Jan 29, 2011·Brazilian Dental Journal·Arthur Belém NovaesAdriano Piattelli
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Tianfang WangHejie Li
Aug 7, 2012·Journal of Applied Biomaterials & Functional Materials·Cinzia Della ValleRoberto Chiesa

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