Dec 31, 1997

Biogenesis of peroxisomes in fetal liver

Microscopy Research and Technique
M EspeelF Roels


Peroxisomes are single membrane-limited cell organelles that are involved in numerous metabolic functions. Peroxisomes do not contain DNA; the matrix and membrane proteins are encoded by the nuclear genome. It is assumed that new peroxisomes are formed by division of existing organelles. The present article gives an overview of microscopic studies and recent unpublished results dealing with peroxisome biogenesis in mammalian fetal liver and presents data on peroxisomes in oocytes. Cytochemical (catalase and D-aminoacid oxidase activity) and immunocytochemical data in rat and human liver (antigens of catalase, the three peroxisomal beta-oxidation enzymes, alanine: glyoxylate aminotransferase, peroxisomal membrane proteins with molecular weights of 42 and 70 kDa) indicate that during embryonic and fetal development the peroxisomal population undergoes a differentiation with respect to the composition of the matrix and to the size and number of the organelles. In the youngest stages, rare and small peroxisomes are present, into which the matrix components are imported in a sequential way. The import seems asynchronous in peroxisomes of the same hepatocyte. The size and number of the peroxisomes increase during liver development. I...Continue Reading

  • References72
  • Citations9


  • References72
  • Citations9


Mentioned in this Paper

Infantile Refsum Disease (Disorder)
Metabolic Process, Cellular
Ovarian Diseases
Granulosa Cell
Entire Fetus
Enzymes, antithrombotic
Both Ovaries
Peroxisomal Dysfunction, Single
Biologic Development

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