Biogenesis of the lysosome-derived vacuole containing Coxiella burnetii

Microbes and Infection
Lara J Kohler, Craig R Roy

Abstract

Coxiella burnetii utilizes a Type IV Secretion System (T4SS) to modify host endomembrane transport systems to form a unique lysosome-derived niche called the Coxiella-containing vacuole (CCV). Although the CCV has lysosomal properties, this organelle displays distinct characteristics such as homotypic fusion and a cholesterol enriched limiting membrane, in addition to robustly interacting with autophagosomes. This review describes recent advances in understanding CCV biogenesis and the mechanisms C. burnetii employs to maintain this unique compartment.

References

Sep 14, 2002·Infection and Immunity·Walter BerónMaria I Colombo
Jun 15, 2005·Cellular Microbiology·Maximiliano G GutierrezMaría I Colombo
Feb 17, 2006·Annals of the New York Academy of Sciences·Dale Howe, Robert A Heinzen
Nov 17, 2007·Genes & Development·Noboru Mizushima
Jul 16, 2009·Nature Reviews. Molecular Cell Biology·Harald Stenmark
Aug 6, 2009·Annual Review of Genetics·Congcong He, Daniel J Klionsky
Feb 11, 2010·Cell·Noboru MizushimaBeth Levine
Mar 3, 2010·Annual Review of Biophysics·Jennifer Lippincott-Schwartz, Robert D Phair
Oct 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Anja LührmannCraig R Roy
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chen ChenJames E Samuel
Dec 6, 2012·Interdisciplinary Perspectives on Infectious Diseases·Hamidreza Honarmand
Dec 12, 2012·Cellular Microbiology·Emanuel Martín CampoyMaría Isabel Colombo
Jan 30, 2013·PLoS Pathogens·Stacey D GilkRobert A Heinzen
Feb 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ziv LifshitzGil Segal
Nov 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Charles L LarsonRobert A Heinzen
Mar 20, 2014·Infection and Immunity·Caylin G WinchellDaniel E Voth

❮ Previous
Next ❯

Citations

May 27, 2016·Proceedings of the National Academy of Sciences of the United States of America·Eric MartinezMatteo Bonazzi
Jul 16, 2016·Future Microbiology·Charles L LarsonMatteo Bonazzi
Nov 29, 2017·Experimental & Applied Acarology·Nicole O Moura-MartinianoCarlos Augusto Gomes Soares
Nov 28, 2017·Molecular Microbiology·Christian OttenJeanne Salje
Jun 22, 2018·Current Protocols in Microbiology·Savannah E SanchezAnders Omsland
Jun 18, 2017·Frontiers in Cellular and Infection Microbiology·Eduardo Vallejo EsquerraAnders Omsland
Mar 25, 2019·Life Science Alliance·Chelsea L CockburnJason A Carlyon
Jun 6, 2018·Frontiers in Cellular and Infection Microbiology·Hélène BierneMounia Kortebi
Dec 14, 2017·Molecular Microbiology·Elisabeth GrohmannSteffen Backert
Sep 16, 2020·Infection and Immunity·Zachary P Howard, Anders Omsland
Mar 29, 2021·Cellular Microbiology·Samuel SteinerCraig R Roy
Jul 15, 2021·Pathogens and Disease·Savannah E Sanchez, Anders Omsland
Sep 8, 2021·Infection and Immunity·Savannah E SanchezAnders Omsland

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.