PMID: 43602Jan 1, 1979

Biogenic amines in neuroendocrine systems: multiple sources, messages, targets and controls

Texas Reports on Biology and Medicine
W B Quay


Biogenic amines are small chemical mediator molecules synthesized from amino acids by the body. Our research has centered on functions and controls of three categories of biogenic amines in neuroendocrine and neural systems of laboratory species of mammals as models of similar processes in the human body. Experimental analyses have been made of possible contributions of particular of these compounds, or their sources, to regulation of reproductive and 24-hour rhythms, and to responses and adaptations to stress. Results from this and related work, by many other investigators as well, have general implications for biomedical research, including: (A) Biogenic amines have multiple sources, messages, targets and possible controls, depending on species (genetics), developmental stage and age, and in relation to tissue regions and responses during both adaptations and disease states. (B) Functions or actions of biogenic amines in either the nervous or the neuroendocrine system go beyond what can be accommodated by the classical paradigms or terms of neurophysiology. Labeling these compounds in their various tissue sites as "neurotransmitters", or "neuromodulators", or "neurohormones" adds little to our understanding of their actions a...Continue Reading

Related Concepts

Neurophysiology - Biologic Function
Amino Acids, I.V. solution additive
Neurosecretory Systems
Mediator of activation protein
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