Bioguided isolation, identification and activity evaluation of antifungal compounds from Acorus tatarinowii Schott.

Journal of Ethnopharmacology
Zhao-Jie WangXiao-Dong Luo

Abstract

As a traditional folk medicine, Acorus tatarinowii Schott was used to treat digestive diseases, such as diarrhea, which may be related to Candida albicans infection; however according to literature surveys, there have been few studies of A. tatarinowii focusing on its antimicrobial activity, and almost all describe investigations using crude extracts or fractions. The aims of the current study were to isolate and identify antifungal fractions of A. tatarinowii based on their antifungal activity, explore the preliminary mechanism of 60% ethanol elution (AT60) by metabonomics, and evaluate the antifungal activity of AT60 in vivo and in vitro, to provide natural resources against fungal infections. As a pilot evaluation of activity, A. tatarinowii fractions and compounds with antifungal bioactivity were isolated by bioactive-guided column chromatography, and identified by LC-QTOF-MS/MS and NMR spectroscopy. The antifungal effects of the active ingredients against resistant C. albicans were evaluated by in vivo and in vitro colony forming unit assays. The mechanism underlying the activity of AT60 against C. albicans was explored using an LC-QTOF-based metabonomics approach and fluorescence microscopy imaging. AT60 showed better act...Continue Reading

References

Feb 17, 2000·The EMBO Journal·D B ParekhP J Parker
Feb 19, 2004·Journal of Agricultural and Food Chemistry·Jee Yeon LeeByung Kook Hwang
Apr 9, 2005·Epilepsia·Wei-Ping LiaoShao-Qing Yang
Sep 30, 2005·Journal of Agricultural and Food Chemistry·C L CantrellD E Wedge
Aug 15, 2006·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·D SanglardJ Bille
Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Apr 1, 2008·Eukaryotic Cell·Leah E Cowen, William J Steinbach
Apr 17, 2010·The Journal of Dermatological Treatment·Hamidreza Pazoki-ToroudiAlireza Firooz
May 25, 2010·Toxicology and Applied Pharmacology·Paul R WestGabriela G Cezar
May 9, 2012·Current Opinion in Microbiology·Antonio Cassone, Arturo Casadevall
May 15, 2012·Science·Gordon D BrownStuart M Levitz
Dec 21, 2012·Science Translational Medicine·Gordon D BrownTheodore C White
Sep 26, 2013·Future Microbiology·Heather T TaffDavid R Andes
Jan 18, 2015·Journal of Medical Microbiology·Mohammad H AfsarianFarzad Katiraee
Feb 19, 2016·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Raimunda S N BrilhanteMarcos F G Rocha
Mar 11, 2016·Scientific Reports·Yuanyuan LuYonghui Zhang
Dec 4, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yuan-Li HuangYong-He Zhang
Jul 4, 2018·European Journal of Medicinal Chemistry·Rahul V PatelHan-Seung Shin
Nov 20, 2018·Frontiers in Microbiology·Lianbao YeZhibin Shen
Jan 23, 2019·Molecular Nutrition & Food Research·Xiaojun LiJinyou Duan

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