Bioinformatic prediction and analysis of eukaryotic protein kinases in the rat genome

Gene
Julhash U KaziJae-Won Soh

Abstract

Eukaryotic protein kinases, containing a conserved catalytic domain, represent one of the largest superfamilies of the eukaryotic proteins and play distinct roles in cell signaling and diseases. Near completion of rat genome sequencing project enables the evaluation of a near complete set of rat protein kinases. Publicly accessible genetic sequence databases were searched for rat protein kinases, and 515 eukaryotic protein kinases, 40 atypical protein kinases and 45 kinase pseudogenes were identified. The rat has 509 putative protein kinases orthologous to human kinases. Unlike microtubule affinity-regulating kinases, the rat has a few more kinases, in addition to the orthologous pairs of mouse kinases. The comparison of 11 different eukaryotic species revealed the evolutionary conservation of this diverse family of proteins. The evolutionary rate studies of human disease and non-disease associated kinases suggested that relatively uniform selective pressures have been applied to these kinase classes. This bioinformatic study of the rat protein kinases provides a suitable framework for further characterization of the functional and structural properties of these protein kinases.

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Citations

Feb 27, 2013·Medical Oncology·Nuzhat N KabirJulhash U Kazi
Jul 31, 2012·Evolutionary Bioinformatics Online·Gideon C-T Wu, Feng-Chi Chen
Apr 8, 2014·Cellular and Molecular Life Sciences : CMLS·Julhash U KaziLars Rönnstrand
Aug 31, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Nuzhat N KabirJulhash U Kazi
Jan 25, 2013·Leukemia & Lymphoma·Nuzhat N KabirJulhash U Kazi
Nov 1, 2013·Medical Oncology·Julhash U KaziLars Rönnstrand
Jan 5, 2012·Genetics and Molecular Biology·Nuzhat N Kabir, Julhash U Kazi
May 9, 2019·Physiological Reviews·Julhash U Kazi, Lars Rönnstrand
Dec 13, 2017·Molecular Neuropsychiatry·Ashwini SaxenaJoão Quevedo
Jan 15, 2014·Molecular Biology Reports·Nuzhat N Kabir, Julhash U Kazi
Nov 29, 2013·Journal of Cell Science·Julhash U KaziLars Rönnstrand
Jul 29, 2021·Journal of Proteome Research·Laura J MarholzMireia Fernandez Ocana

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