Bioinformatical and in vitro approaches to essential oil-induced matrix metalloproteinase inhibition

Pharmaceutical Biology
Fares Zeidán-ChuliáUlvi K Gursoy

Abstract

Essential oils carry diverse antimicrobial and anti-enzymatic properties. Matrix metalloproteinase (MMP) inhibition characteristics of Salvia fruticosa Miller (Labiatae), Myrtus communis Linnaeus (Myrtaceae), Juniperus communis Linnaeus (Cupressaceae), and Lavandula stoechas Linnaeus (Labiatae) essential oils were evaluated. Chemical compositions of the essential oils were analyzed by gas chromatography-mass spectrometry (GC-MS). Bioinformatical database analysis was performed by STRING 9.0 and STITCH 2.0 databases, and ViaComplex software. Antibacterial activity of essential oils against periodontopathogens was tested by the disc diffusion assay and the agar dilution method. Cellular proliferation and cytotoxicity were determined by commercial kits. MMP-2 and MMP-9 activities were measured by zymography. Bioinformatical database analyses, under a score of 0.4 (medium) and a prior correction of 0.0, gave rise to a model of protein (MMPs and tissue inhibitors of metalloproteinases) vs. chemical (essential oil components) interaction network; where MMPs and essential oil components interconnected through interaction with hydroxyl radicals, molecular oxygen, and hydrogen peroxide. Components from L. stoechas potentially displayed ...Continue Reading

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Citations

Apr 12, 2013·Chemistry & Biodiversity·Fares Zeidán-ChuliáVeli-Jukka Uitto
Dec 3, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Amel BouzabataLigia Salgueiro
Mar 19, 2014·Archives of Oral Biology·Fares Zeidán-ChuliáVeli-Jukka Uitto
Mar 9, 2018·Medical Sciences : Open Access Journal·Ben-Hur Neves de OliveiraFares Zeidán-Chuliá
Jun 2, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Karla Suzana MorescoJosé Cláudio Fonseca Moreira

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