Abstract
Postmenopausal osteoporosis (PMOP), as well as its associated increased risk for fragility fracture, is one of the most disabling consequences of aging in women. This present study aimed to identify candidate genes that involve pathogenesis of PMOP and the therapeutic mechanism of Liuweidihuang (LWDH) pills on PMOP. We integrated microarray datasets of PMOP derived from the Gene Expression Omnibus (GEO) to screen differentially expressed genes (DEGs) between PMOP and normal controls as well as patients with PMOP and patients after treatment of LWDH pills. GO and KEGG enrichment analysis for DEGs were performed. The shared DEGs, associated with both the pathogenesis of PMOP and the therapeutic mechanism of LWDH, were further analyzed by protein-protein interaction (PPI) network. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to verify the DEGs obtained by our integrated analysis. Compared with normal controls, 1732 DEGs in PMOP were obtained with p<0.05. According to the qRT-PCR results, expression of ATF2, FBXW7, RDX, and RBBP4 was consistent with that in our integrated analysis, generally. GO and KEGG enrichment analysis showed that those DEGs were significantly enriched in regulation of transcription...Continue Reading
References
Sep 1, 1993·Journal of Internal Medicine·C WüsterR Ziegler
Dec 4, 2008·The American Journal of Chinese Medicine·Yi FengYilun Tan
Feb 18, 2010·Clinical Orthopaedics and Related Research·Julius Wolff
Oct 23, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Manyu LiXijun Wang
May 1, 2013·BMC Bioinformatics·Lifang ZhangMenglong Li
Jun 14, 2013·Clinical & Developmental Immunology·Maria Felicia FaienzaLuciano Cavallo
Mar 29, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kazuki Inoue, Yuuki Imai
Jul 19, 2014·World Journal of Orthopedics·Graziana ColaianniMaria Grano
Oct 3, 2015·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Lixiang ZhengYue Wang
Apr 9, 2016·Molecular Cancer·Mayakannan ManikandanArasambattu Kannan Munirajan
May 3, 2016·Journal of Physical Therapy Science·Min Hee Kim, Hae-Jeung Lee
Dec 7, 2016·Scientific Reports·Jacobus F A JansenWalter H Backes
Dec 17, 2016·Scientific Reports·A HartiganA S Holzer
Dec 29, 2016·Chinese Journal of Integrative Medicine·Ji-Rong GeChen-Bo Ni
Mar 21, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Li-Zhi XingYu-Ling Wang
May 4, 2017·European Journal of Haematology·Yong YangQi Fei
Jun 28, 2017·BMC Ophthalmology·Bin ZhaoYuhui Yu
Jul 8, 2017·Nature Communications·Mi YangXiang-Hang Luo
Sep 2, 2017·Journal of Applied Physiology·D SaulS Sehmisch
Sep 11, 2017·FEBS Letters·Shota HirumaRyota Uehara
Nov 9, 2017·Expert Opinion on Biological Therapy·Maria Felicia FaienzaGiacomina Brunetti
Dec 6, 2017·International Journal of Molecular Medicine·Qian LiuZuolin Jin
May 11, 2018·The Journal of Spinal Cord Medicine·Nour ZleikLaura Carbone
Dec 12, 2018·Scientific Reports·Ravindra TawareSrikanth Rapole