Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and apigenin against cervical squamous cell carcinoma and adenocarcinoma

Oncotarget
Pei-Ming YangChien-Fu Hung

Abstract

The clinical management and treatment of cervical cancer, one of the most commonly diagnosed cancers and a leading cause of cancer-related female death, remains a huge challenge for researchers and health professionals. Cervical cancer can be categorized into two major subtypes: common squamous cell carcinoma (SCC) and adenocarcinoma (AC). Although it is a relatively rare histological subtype of cervical cancer, there has been a steady increase in the incidences of AC. Therefore, new strategies to treat cervical cancer are urgently needed. In this study, the potential uses of IFNγ-based therapy for cervical cancer were evaluated using bioinformatics approaches. Gene expression profiling identified that cell cycle dysregulation was a major hallmark of cervical cancer including SCC and AC subtypes, and was associated with poor clinical outcomes for cervical cancer patients. In silico and in vitro experimental analyses demonstrated that IFNγ treatment could reverse the cervical cancer hallmark and induce cell cycle arrest and apoptosis. Furthermore, we demonstrated that apigenin could enhance the anticancer activity of IFNγ in a HeLa cervical AC cell line by targeting cyclin-dependent kinase 1. Taken together, the present study su...Continue Reading

References

Apr 1, 1997·Journal of Biochemistry·A KanoT Akaike
Jun 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F BurkeF R Balkwill
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C.-H. LaiJ.-D. Lin
Jun 5, 2002·Nature Reviews. Cancer·Harald zur Hausen
Oct 7, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Angéline GradolattoMarie-Chantal Canivenc-Lavier
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Oct 19, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sanjeev ShuklaSanjay Gupta
Nov 18, 2005·Toxicology·Tajdar Husain Khan, Sarwat Sultana
Feb 2, 2006·International Journal of Cancer. Journal International Du Cancer·Angel ChaoChyong-Huey Lai
Jun 29, 2007·Bioinformation·Mehdi PiroozniaYouping Deng
Nov 3, 2009·Gynecologic Oncology·Lilian T GienGillian Thomas
Jan 16, 2010·Annals of the New York Academy of Sciences·Catriona H T MillerHoward A Young
Mar 23, 2010·Pharmaceutical Research·Sanjeev Shukla, Sanjay Gupta
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 28, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·M Raza Zaidi, Glenn Merlino
Jul 17, 2012·International Journal of Pharmaceutics·Jianjun ZhangShuai Qian
Dec 25, 2012·Current Cancer Drug Targets·Grace P C YeeLevon M Khachigian
May 28, 2013·International Journal of Oncology·Yong-Wan KimWoong Shick Ahn
Aug 24, 2013·International Journal of Oncology·Daniele MaggioniGabriella Nicolini
Oct 23, 2013·Gynecologic Oncology·Yoo-Young LeeByoung-Gie Kim
Dec 3, 2013·Nucleic Acids Research·Michael KuhnPeer Bork
Aug 16, 2014·Pharmacognosy Reviews·Katrin Sak
Oct 30, 2014·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Dec 19, 2014·BMC Cancer·Chirayu Pankaj Goswami, Harikrishna Nakshatri
Jun 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Johan A den BoonPaul Ahlquist

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Citations

Sep 22, 2019·International Journal of Molecular Sciences·Itika AroraTrygve O Tollefsbol
Jun 2, 2018·Biomolecular Concepts·Gunjan KakBrijendra K Tiwari
Oct 17, 2017·Cell & Bioscience·Xiaohui YanHuanjie Shao
Dec 18, 2020·Life Sciences·Semim Akhtar AhmedAjaikumar B Kunnumakkara
Dec 15, 2020·Journal of Molecular Biology·Pamali FonsekaSuresh Mathivanan
Oct 31, 2021·Cancer Cell International·Zahra NozhatAmirhossein Ahmadi

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Datasets Mentioned

BETA
GSE39001
GSE7803
GSE63514

Methods Mentioned

BETA
flow cytometry
biopsy

Software Mentioned

GSEA
Venny
Connectivity Map ( CMap )
WinMDI
GEO2R
FunRich
CompuSyn
Search Tool for Interactions ( STITCH
CMap
Search Tool for the Retrieval of Interacting Genes Proteins ( ...

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