Bioinformatics Tools for Genome-Wide Epigenetic Research

Advances in Experimental Medicine and Biology
Vladimir Espinosa Angarica, Antonio Del Sol

Abstract

Epigenetics play a central role in the regulation of many important cellular processes, and dysregulations at the epigenetic level could be the source of serious pathologies, such as neurological disorders affecting brain development, neurodegeneration, and intellectual disability. Despite significant technological advances for epigenetic profiling, there is still a need for a systematic understanding of how epigenetics shapes cellular circuitry, and disease pathogenesis. The development of accurate computational approaches for analyzing complex epigenetic profiles is essential for disentangling the mechanisms underlying cellular development, and the intricate interaction networks determining and sensing chromatin modifications and DNA methylation to control gene expression. In this chapter, we review the recent advances in the field of "computational epigenetics," including computational methods for processing different types of epigenetic data, prediction of chromatin states, and study of protein dynamics. We also discuss how "computational epigenetics" has complemented the fast growth in the generation of epigenetic data for uncovering the main differences and similarities at the epigenetic level between individuals and the ...Continue Reading

Citations

Feb 15, 2019·PLoS Computational Biology·Ana Julia Velez RuedaGustavo Parisi
Jul 28, 2019·Immunology·Candace C LiuAaron M Newman
Feb 6, 2020·Genome Biology·Feng YanNicholas C Wong
Jul 10, 2020·Methods : a Companion to Methods in Enzymology·Yuanyuan Li
Feb 10, 2021·Journal of Molecular and Cellular Cardiology·Matthew A Fischer, Thomas M Vondriska
Jul 14, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yan LiuLin Zhao

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