Bioinspired and Mechanically Strong Fibers Based on Engineered Non-Spider Chimeric Proteins.

Angewandte Chemie
Yuanxin LiHongjie Zhang

Abstract

Silk-protein-based fibers have attracted considerable interest due to their low weight and extraordinary mechanical properties. Most studies on fibrous proteins focus on the recombinant spidroins, but these fibers exhibit moderate mechanical performance. Thus, the development of alternative structural proteins for the construction of robust fibers is an attractive goal. Herein, we report a class of biological fibers produced using a designed chimeric protein, which consists of the sequences of a cationic elastin-like polypeptide and a squid ring teeth protein. Remarkably, the chimeric protein fibers exhibit a breaking strength up to about 630 MPa and a corresponding toughness as high as about 130 MJ m-3 , making them superior to many recombinant spider silks and even comparable to some native counterparts. Therefore, this strategy is a novel concept for exploring bioinspired ultrastrong protein materials through the development of new types of structural chimeric proteins.

References

Sep 14, 2006·Chemical Reviews·Randolph V Lewis
Dec 2, 2008·Macromolecular Bioscience·Hui ShaoRussell J Stewart
Feb 13, 2009·Angewandte Chemie·Markus HeimThomas Scheibel
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Xia XiaSang Yup Lee
Aug 2, 2011·Nature Chemical Biology·Jing YuJ Herbert Waite
Nov 23, 2012·Advanced Materials·Zhi LinDaiwen Yang
Feb 18, 2015·Advanced Materials·Aniela HeidebrechtThomas Scheibel
Apr 12, 2016·ACS Biomaterials Science & Engineering·Cameron G CopelandRandolph V Lewis
May 26, 2016·Proceedings of the National Academy of Sciences of the United States of America·Huihun JungMelik C Demirel
Jan 10, 2017·Nature Chemical Biology·Marlene AnderssonAnna Rising
Nov 11, 2017·Nature Communications·Shengjie LingMarkus J Buehler
Feb 15, 2018·Advanced Materials·Ying CuiHao Bai
Mar 9, 2019·Frontiers in Chemistry·Abdon Pena-Francesch, Melik C Demirel
Apr 2, 2019·Nature Communications·Taiyo YoshiokaTsunenori Kameda
May 3, 2019·Communications Biology·Nobuaki KonoKazuharu Arakawa
Jan 12, 2020·Communications Biology·Nobuaki KonoKazuharu Arakawa
Jan 17, 2020·Advanced Materials·Chao MaAndreas Herrmann
Mar 14, 2016·ACS Biomaterials Science & Engineering·Amit YaariOded Shoseyov

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Citations

Jun 25, 2020·Small·Baiheng WuDavid A Weitz
May 24, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bin LiuKai Liu
Jul 13, 2021·ACS Biomaterials Science & Engineering·Diego López BarreiroCees M J Sagt
Oct 9, 2021·Chemistry : a European Journal·Jing SunHongjie Zhang

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