Bioinspired exosome-like therapeutics and delivery nanoplatforms

Biomaterials
Mei Lu, Yuanyu Huang

Abstract

Exosomes have emerged as appealing candidate therapeutic agents and delivery nanoplatforms due to their endogenous features and unique biological properties. However, obstacles such as low isolation yield, considerable complexity and potential safety concerns, and inefficient drug payload substantially hamper their therapeutic applicability. To this end, developing bioinspired exosome-like nanoparticles has become a promising area to overcome certain limitations of their natural counterparts. Synthetically fabrication of exosome-like nanoparticles that harbor only crucial components of exosomes through controllable protocols strongly increases the pharmaceutical acceptability of these vesicles. Assembly of exosome-like nanovesicles derived from producer cells allows for a promising strategy for scale-up production. To improve the loading capability and delivery efficiency of exosomes, hybrid exosome-like nanovesicles and membrane-camouflaged nanoparticles towards better bridging synthetic nanocarriers with natural exosomes could be designed. Building off these observations, herein, efforts are made to give an overview of bioinspired exosome-like therapeutics and delivery nanoplatforms. We briefly recapitulate the recent advance...Continue Reading

References

Mar 1, 1996·The Journal of Experimental Medicine·G RaposoH J Geuze
Apr 4, 2003·Biotechnology and Bioengineering·Enhong CaoPeter R Foster
Feb 23, 2005·Journal of Translational Medicine·Michael A MorseH Kim Lyerly
Jun 27, 2006·Journal of Cellular and Molecular Medicine·G MignotL Zitvogel
Jul 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lawrence RajendranKai Simons
Jan 29, 2008·Recent Patents on Cardiovascular Drug Discovery·Luciano C P AzevedoFrancisco R M Laurindo
Mar 1, 2008·Science·Katarina TrajkovicMikael Simons
Mar 26, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shengming DaiGuisheng Li
Apr 7, 2009·Journal of Immunological Methods·Hugo De La PeñaItalo A Dodi
Apr 16, 2009·Journal of Proteome Research·Javier Conde-VancellsJuan M Falcon-Perez
Jun 6, 2009·Traffic·Susanne StuffersAndreas Brech
Jun 6, 2009·Nature Reviews. Immunology·Clotilde ThéryElodie Segura
Nov 13, 2009·Gene Therapy·S Nayak, R W Herzog
May 12, 2010·Immunology and Cell Biology·Sonja I BuschowWillem Stoorvogel
May 28, 2010·Arthritis and Rheumatism·Luis Martinez-LostaoAlberto Anel
Jun 24, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Dongmei SunHuang-Ge Zhang
Nov 9, 2010·Communicative & Integrative Biology·Anoek ZomerD Michiel Pegtel
Mar 23, 2011·Nature Biotechnology·Lydia Alvarez-ErvitiMatthew J A Wood
Mar 25, 2011·Biochemical Society Transactions·Sanyukta Rana, Margot Zöller
Apr 12, 2011·Nature Biotechnology·Jasper G van den BoornGunther Hartmann
Apr 19, 2011·Nature Reviews. Genetics·Federico Mingozzi, Katherine A High
Jun 8, 2011·Traffic·Angélique BobrieClotilde Théry
Jul 2, 2011·Nature Reviews. Drug Discovery·Jin-Wook YooSamir Mitragotri
Sep 15, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xiaoying ZhuangHuang-Ge Zhang
Feb 9, 2012·Chemical Society Reviews·Rubul MoutVincent M Rotello
Feb 9, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Casey A MaguireJohan Skog
Jul 27, 2012·Therapeutic Delivery·Carmen Gutiérrez MillánJosé M Lanao
Aug 21, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luana LuginiStefano Fais
Aug 28, 2012·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Günter Müller
Sep 11, 2012·Biotechnology Advances·Ruenn Chai LaiSai Kiang Lim
Oct 4, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shin-ichiro OhnoMasahiko Kuroda
Jan 25, 2013·International Journal of Molecular Sciences·Hsin-Hui ShenLisa Martin
Feb 20, 2013·Cancer Letters·Mark KatakowskiMichael Chopp
Feb 20, 2013·The Journal of Cell Biology·Graça Raposo, Willem Stoorvogel
Apr 16, 2013·Nature Reviews. Drug Discovery·Samir EL AndaloussiMatthew J A Wood
Jun 12, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Songwen JuHuang-Ge Zhang
Jul 25, 2013·Pharmaceutical Research·Antonio P CostaDiane J Burgess

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Citations

Jun 21, 2020·Signal Transduction and Targeted Therapy·Bo HuXing-Jie Liang
Aug 14, 2020·International Reviews of Immunology·Yuyang HouDong Li
Aug 28, 2020·International Journal of Molecular Sciences·Simona VillataValentina Cauda
Oct 24, 2020·Macromolecular Bioscience·Carmen Gutierrez-MillanClara I Colino
Dec 23, 2020·Nanoscale·Li DuanJiang Xia
Feb 2, 2021·International Journal of Nanomedicine·Sree Pooja VarahachalamAjeet Kaushik
Jan 13, 2021·Journal of Nanobiotechnology·Lei CaoLei Wang
Mar 2, 2021·Advanced Materials·Xu ZhangHélder A Santos
Apr 4, 2021·Biomolecules·Renata Caroline Costa de FreitasElena Aikawa
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Haroon KhanGuo-Yuan Yang
Jun 21, 2021·Advanced Drug Delivery Reviews·Alice GrangierAmanda K A Silva
Aug 3, 2021·Journal of Drug Delivery Science and Technology·Bhaargavi AshokMarissa E Wechsler
Aug 3, 2021·Analytical Cellular Pathology (Amsterdam)·Tina B McKayJoseph B Ciolino
Aug 14, 2021·Journal of Nanobiotechnology·Yong-Jiang LiDa-Xiong Xiang
Aug 25, 2021·ACS Biomaterials Science & Engineering·Kun LiYuanyu Huang
Sep 5, 2021·Journal of Hematology & Oncology·Zhijie WengLongjiang Li
Sep 17, 2021·International Journal of Pharmaceutics·Shilpa Lekhraj Peswani SajnaniDriton Vllasaliu
Nov 2, 2021·ACS Nano·Sara Hassanpour TamrinArindom Sen

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