Bioinspired Hydrogels for 3D Organoid Culture

Chimia
Delphine Blondel, Matthias P Lutolf

Abstract

Organoids have stepped into the limelight as unique in vitro systems for modeling organ development, function and disease. This review provides a perspective on how chemically defined, bio-inspired hydrogels could be used for replacing ill-defined matrices derived from the native extracellular matrix (ECM) that are used for generating organoids in 3D stem cell culture. In particular, we propose the use of self-healing and light-responsive matrices that should afford control over the inherently stochastic self-organization process that currently underlies organoid morphogenesis. Such designer ECMs could accelerate the translation of organoid technology from the laboratory into various real-life applications.

Citations

Jul 28, 2019·Current Opinion in Organ Transplantation·Ivan MartinNicolas C Rivron
Apr 15, 2020·Annals of Biomedical Engineering·Katya D'CostaMilica Radisic
Aug 28, 2020·Frontiers in Bioengineering and Biotechnology·Steven N SteinwayDeok-Ho Kim
Nov 6, 2020·Developmental Biology·Nicola GrittiVikas Trivedi
Nov 23, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Allison LewisAnne Grapin-Botton
Mar 4, 2021·American Journal of Physiology. Cell Physiology·Dimitrios I Zeugolis
Mar 2, 2021·Advanced Science·Barbara Blanco-FernandezJoão F Mano
Mar 1, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Sanchita RauthMoorthy P Ponnusamy
Mar 20, 2021·Journal of Tissue Engineering·Moshe J WillnerKam W Leong
Jun 10, 2021·Journal of Tissue Engineering·Justine CreffArnaud Besson
Aug 3, 2021·Frontiers in Cell and Developmental Biology·Hongyu LiZhaohui Li
Sep 3, 2021·Chemical Reviews·Franck J VernereyStephanie J Bryant
Sep 29, 2021·Biology of the Cell·Jad SalehWang Xi

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