Bioinspired multilayer membranes as potential adhesive patches for skin wound healing.

Biomaterials Science
Maria P SousaJoão F Mano

Abstract

Bioinspired and adhesive multilayer membranes are produced using the layer-by-layer (LbL) assembly of chitosan (CHT), alginate (ALG) and hyaluronic acid modified with dopamine (HA-DN). Freestanding multilayer membranes without DN are also produced as a control. The success of the synthesis of HA-DN was confirmed using UV-visible spectroscopy. Scanning electron microscopy images indicate that the surface of the DN-containing membranes is more porous than the control ones; they also present a higher average thickness value for the same number of CHT/ALG/CHT/HA(-DN) tetralayers (n = 100). Also, water uptake, mechanical strength and adhesion are enhanced with the introduction of DN moieties along the nano-layers. Besides, human dermal fibroblast viability, enhanced adhesion and proliferation were confirmed by immunofluorescence assays and by measuring both the metabolic activity and DNA content. Moreover, in vivo assays with such kinds of DN-containing multilayer membranes were performed; the application of these membranes in the treatment of dermal wounds induced in Wistar rats results in the highest decrease of inflammation of rat skin, compared with the control conditions. Overall, this investigation suggests that these mussel-i...Continue Reading

References

Apr 1, 1994·Biomaterials·S P ZhongD F Williams
May 14, 1993·Science·R Langer, J P Vacanti
Dec 1, 2001·British Journal of Plastic Surgery·E Dantzer, F M Braye
Jan 26, 2007·Journal of the Royal Society, Interface·Anthony D Metcalfe, Mark W J Ferguson
Jul 20, 2007·Nature·Haeshin LeePhillip B Messersmith
Oct 9, 2008·Advanced Functional Materials·Kefeng RenCatherine Picart
Apr 28, 2011·Biomacromolecules·Felix SimaIon N Mihailescu
Oct 11, 2011·Journal of the American Academy of Dermatology·Katarzyna Skórkowska-TelichowskaJan Szopa
Nov 8, 2011·Annual Review of Materials Research·Bruce P LeeJ H Waite
Dec 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Guoming SunSharon Gerecht
Jul 17, 2012·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J M Reinke, H Sorg
Nov 28, 2012·Advanced Materials·Josep SedóDaniel Ruiz-Molina
Mar 19, 2013·Advanced Drug Delivery Reviews·Wojciech Chrzanowski, Ali Khademhosseini
Mar 21, 2013·Journal of Burn Care & Research : Official Publication of the American Burn Association·Kathleen M GuthrieMichael J Schurr
Apr 18, 2013·Biomacromolecules·Sofia G CaridadeCatherine Picart
May 16, 2013·Tissue Engineering. Part B, Reviews·Qiu Li Loh, Cleo Choong
Aug 29, 2013·Advanced Healthcare Materials·Joana M SilvaJoão F Mano
Dec 21, 2013·Journal of Biomechanical Engineering·Edward A SanderSteven T Boyce
Feb 20, 2014·Chemical Society Reviews·Rui R Costa, João F Mano
Jul 20, 2014·Carbohydrate Polymers·Sónia P MiguelIlídio J Correia
Aug 16, 2014·Advances in Wound Care·Aditya SoodNancy L Tomaselli
Aug 21, 2014·Chemical Reviews·João Borges, João F Mano
Sep 23, 2014·Biomacromolecules·Joana M SilvaJoão F Mano
Sep 30, 2014·Advanced Healthcare Materials·Florence CroisierChristine Jérôme
Feb 28, 2015·Advanced Healthcare Materials·Mohammad NorouziMasoud Soleimani
Mar 31, 2015·Nature Communications·Wen YangMarc A Meyers
Dec 29, 2015·ACS Applied Materials & Interfaces·Chetna DhandRajamani Lakshminarayanan
Aug 25, 2016·Plastic and Reconstructive Surgery·Mayer Tenenhaus, Hans-Oliver Rennekampff
Nov 30, 2016·International Journal of Molecular Sciences·Atul A ChaudhariShreekumar R Pillai
Dec 15, 2016·Chemical Reviews·Joseph J RichardsonFrank Caruso

❮ Previous
Next ❯

Citations

Dec 24, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ceren KimnaFunda Tihminlioglu
Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joana MoreiraNatália M Alves
Aug 23, 2020·Pharmaceutics·Martin T MatterInge K Herrmann
Jan 12, 2021·International Journal of Biological Macromolecules·J B M Rocha NetoM M Beppu
Jan 3, 2021·International Journal of Biological Macromolecules·Nahideh AsadiNasim Annabi
Jan 12, 2021·Nano Today·Ayça Bal-OzturkShabir Hassan
Mar 7, 2021·Micromachines·Mikail TemirelSavas Tasoglu
Apr 16, 2021·ACS Nano·Yu WangYuanjin Zhao
Jun 27, 2021·Advanced Healthcare Materials·Mojtaba Farahani, Abbas Shafiee
Jul 10, 2019·ACS Applied Materials & Interfaces·Pegah Esmaeilzadeh, Thomas Groth
Oct 12, 2021·International Journal of Biological Macromolecules·Hamed NosratiMehdi Banitalebi-Dehkordi

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
dissection
QCM-D

Software Mentioned

GraphPad Prism
Zeiss
Sense
QTools

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.