Bioinspired pH- and Temperature-Responsive Injectable Adhesive Hydrogels with Polyplexes Promotes Skin Wound Healing

Biomacromolecules
Thai Minh Duy LeDoo Sung Lee

Abstract

Despite great potential, the delivery of genetic materials into cells or tissues of interest remains challenging owing to their susceptibility to nuclease degradation, lack of permeability to the cell membrane, and short in vivo half-life, which severely restrict their widespread use in therapeutics. To surmount these shortcomings, we developed a bioinspired in situ-forming pH- and temperature-sensitive injectable hydrogel depot that could control the delivery of DNA-bearing polyplexes for versatile biomedical applications. A series of multiblock copolymer, comprised of water-soluble poly(ethylene glycol) (PEG) and pH- and temperature-responsive poly(sulfamethazine ester urethane) (PSMEU), has been synthesized as in situ-forming injectable hydrogelators. The free-flowing PEG-PSMEU copolymer sols at high pH and room temperature (pH 8.5, 23 °C) were transformed to stable gel at the body condition (pH 7.4, 37 °C). Physical and mechanical properties of hydrogels, including their degradation rate and viscosity, are elegantly controlled by varying the composition of urethane ester units. Subcutaneous administration of free-flowing PEG-PSMEU copolymer sols to the dorsal region of Sprague-Dawley rats instantly formed hydrogel depot. Th...Continue Reading

References

Nov 17, 2001·Chemical Reviews·K Y Lee, D J Mooney
Mar 22, 2002·Nature Reviews. Cancer·F McCormick
Feb 3, 2005·Nature Reviews. Drug Discovery·Vladimir P Torchilin
Feb 6, 2007·Clinics in Dermatology·Sabine A EmingJeffrey M Davidson
Jul 24, 2008·Chemical Society Reviews·Lin Yu, Jiandong Ding
Dec 6, 2008·Molecular Pharmaceutics·Sun Hwa KimDavid A Bull
Feb 8, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuguo LeiTatiana Segura
Mar 1, 2012·Chemical Reviews·Tina VermondenWim E Hennink
Jun 6, 2012·ACS Nano·Young-Min KimSoo-Chang Song
Jun 13, 2012·Chemical Society Reviews·Hyo Jung MoonByeongmoon Jeong
Nov 12, 2013·Biomaterials·Talar TokatlianTatiana Segura
Jan 28, 2014·ACS Applied Materials & Interfaces·Xiaomeng LiGuolin Wu
Mar 29, 2014·Biologics : Targets & Therapy·Nataša Skalko-Basnet
Oct 8, 2014·Nature Reviews. Drug Discovery·Vladimir P Torchilin
Feb 11, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cornelia LorenzerJohannes Winkler
Mar 5, 2015·Journal of Clinical and Diagnostic Research : JCDR·Murali Ramamoorth, Aparna Narvekar
May 9, 2015·Advanced Materials·Ting-Chen TsengShan-hui Hsu
Oct 17, 2015·Biomaterials·Myra Noemi ChávezJosé Tomás Egaña
Oct 18, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Samantha M SarettCraig L Duvall
Dec 8, 2015·Advanced Healthcare Materials·Cong Truc HuynhEben Alsberg
Oct 19, 2016·Macromolecular Rapid Communications·Thavasyappan ThambiDoo Sung Lee
Oct 28, 2016·ACS Applied Materials & Interfaces·Yipei ChenJiandong Ding
Nov 12, 2016·Nature Reviews. Cancer·Jinjun ShiOmid C Farokhzad
Apr 5, 2017·Biomaterials·Nicole R RaiaDavid L Kaplan
Apr 21, 2017·Science Translational Medicine·Nadine LohmannUwe Freudenberg
Jul 6, 2017·Biomacromolecules·Sooyoun LimDukjoon Kim
Oct 6, 2017·Science Translational Medicine·Nasim AnnabiAli Khademhosseini
Oct 14, 2017·Nature Reviews. Cancer·Michael J MitchellRobert Langer

❮ Previous
Next ❯

Citations

Apr 5, 2019·Advanced Healthcare Materials·Rattapol PinnaratipBruce P Lee
Oct 31, 2019·Polymers·Zhen QiaoHai-Feng Ji
Jul 17, 2020·The Journal of Chemical Physics·Fabian GrünewaldSiewert J Marrink
Oct 20, 2020·Advanced Healthcare Materials·Fabio Rizzo, Nermin Seda Kehr
Dec 5, 2020·Advanced Healthcare Materials·Fatemeh PoustchiMohammad-Ali Shahbazi
Jan 12, 2021·Nano Today·Ayça Bal-OzturkShabir Hassan
Dec 15, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yi LiDoo Sung Lee
Sep 22, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Parinaz AbdollahiyanAhad Mokhtarzadeh
May 4, 2021·Chemical Reviews·Ramya KumarTheresa M Reineke
Jun 27, 2021·Advanced Healthcare Materials·Mojtaba Farahani, Abbas Shafiee
Aug 7, 2021·Frontiers in Bioengineering and Biotechnology·Shuai ChenVahid Serpooshan
Aug 20, 2021·ACS Applied Materials & Interfaces·Hossein MontazerianPaul S Weiss
May 17, 2019·Biomacromolecules·Xu ZhangGuo-Qiang Chen
Jul 11, 2019·Accounts of Chemical Research·Etienne PiantanidaLuisa De Cola
Jan 29, 2021·Chemical Reviews·Sungmin Nam, David Mooney
Nov 19, 2021·Expert Opinion on Biological Therapy·Parisa GhandforoushanGorka Orive

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.