Biokinetic Modeling and Dosimetry for Optimizing Intraperitoneal Radioimmunotherapy of Ovarian Cancer Microtumors

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Stig PalmPer Albertsson

Abstract

A biokinetic model was constructed to evaluate and optimize various intraperitoneal radioimmunotherapies for micrometastatic tumors. The model was used to calculate the absorbed dose to both anticipated microtumors and critical healthy organs and demonstrated how intraperitoneal targeted radiotherapy can be optimized to maximize the ratio between them. The various transport mechanisms responsible for the biokinetics of intraperitoneally infused radiolabeled monoclonal antibodies (mAbs) were modeled using a software package. Data from the literature were complemented by pharmacokinetic data derived from our clinical phase I study to set parameter values. Results using the β-emitters (188)Re, (177)Lu, and (90)Y and the α-emitters (211)At, (213)Bi, and (212)Pb were compared. The effects of improving the specific activity, prolonging residence time by introducing an osmotic agent, and varying the activity concentration of the infused agent were investigated. According to the model, a 1.7-L infused saline volume will decrease by 0.3 mL/min because of lymphatic drainage and by 0.7 mL/min because of the transcapillary convective component. The addition of an osmotic agent serves to lower the radiation dose to the bone marrow. Clinical...Continue Reading

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Citations

Jan 20, 2017·The British Journal of Radiology·Matthew GardnerElizabeth A Larkin
Feb 23, 2020·Cancer Biotherapy & Radiopharmaceuticals·Sture LindegrenEmma Aneheim
Mar 7, 2019·Current Medicinal Chemistry·Benjamin B KastenDonald J Buchsbaum
Nov 7, 2019·Scientific Reports·Emma AneheimSture Lindegren
Jun 20, 2020·Cancer Biotherapy & Radiopharmaceuticals·Francisco D C Guerra LiberalKevin M Prise
Jan 21, 2017·Nuclear Medicine and Biology·Benjamin B KastenDonald J Buchsbaum
Feb 8, 2018·Nuclear Medicine and Biology·Benjamin B KastenDonald J Buchsbaum
Jan 27, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Andreas HallqvistPer Albertsson
Nov 28, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Stig PalmPer Albertsson

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