PMID: 9420819Sep 1, 1995Paper

Biokinetics and dosimetry analysis in healthy volunteers for a two-injection (rest-stress) protocol of the myocardial perfusion imaging agent technetium 99m-labeled Q3

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
R C RoheH R Maxon

Abstract

Trans (N,N'-ethylene bis(acetylacetoneimine)) bis(tris(3-methoxy-1-propyl) phosphine) 99mTc(III) (99mTc-Q3) has been developed for myocardial perfusion imaging. Biokinetic studies and dosimetry analysis have been completed for six healthy volunteers. The same-day two-injection protocol involved (1) an average rest injection of 241 MBq of 99mTc-Q3 followed by myocardial single-photon emission computed tomography (SPECT) at 15.0 minutes and a whole body (WB) scan at 1.5 hours; and (2) an average stress injection during treadmill exercise of 744 MBq of 99mTc-Q3 at 2.4 hours (postrest injection) followed by myocardial SPECT and additional WB scans at 1.5, 3.5, 6.5, and 21 hours poststress injection. Total urine was collected over 24 hours. Absolute organ activities were determined by conjugate counting methods. The two-injection data were simplified to a one-injection equivalent data set to facilitate dosimetry analysis. Decay corrected average percentage uptake values, plus or minus one standard deviation, for the myocardium were 1.4% +/- 0.2% at approximately 1.5 hours for both the postrest and poststress injections. The average biologic half-time for the myocardium was 26.4 hours. The highest organ uptake values included the gal...Continue Reading

References

Jul 1, 1976·Medical Physics·S R ThomasJ G Kereiakes
Feb 1, 1990·Circulation·D K Glover, R D Okada
Mar 1, 1994·Circulation·M C GersonR C Elder
Nov 1, 1994·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·M C GersonR A Walsh

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Citations

Nov 1, 1994·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·M C GersonR A Walsh
Oct 2, 2007·Journal of Cardiovascular Medicine·Subha V Raman, Marshall W Winner
Aug 7, 2013·Clinical Nuclear Medicine·Shi GaoQingjie Ma
Jul 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Corrado CittantiAdriano Duatti

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