Biolighted Nanotorch Capable of Systemic Self-Delivery and Diagnostic Imaging

ACS Nano
Ajay SinghSehoon Kim

Abstract

Sensitive imaging of inflammation with a background-free chemiluminescence (CL) signal has great potential as a clinically relevant way of early diagnosis for various inflammatory diseases. However, to date, its feasibility has been limitedly demonstrated in vivo with locally induced inflammation models by in situ injection of CL probes. To enable systemic disease targeting and imaging by intravenous administration of CL probes, hurdles need to be overcome such as weak CL emission, short glowing duration, or inability of long blood circulation. Here, we report a CL nanoprobe (BioNT) that surmounted such limitations to perform precise identification of inflammation by systemic self-delivery to the pathological tissues. This BioNT probe was engineered by physical nanointegration of multiple kinds of functional molecules into the ultrafine nanoreactor structure (∼15 nm in size) that combines solid-state fluorescence-induced enhanced peroxalate CL and built-in machinery to control the intraparticle kinetics of CL reaction. Upon intravenous injection into a normal mouse, BioNT showed facile blood circulation and generated a self-lighted strong CL torchlight throughout the whole body owing to the tiny colloidal structure with an anti...Continue Reading

References

Jun 5, 2003·Nature Medicine·Christopher W Pugh, Peter J Ratcliffe
Jun 5, 2007·Nature Protocols·David D BrandEdward F Rosloniec
Aug 19, 2007·Nature Reviews. Molecular Cell Biology·Marco GiorgioPier Giuseppe Pelicci
Aug 21, 2007·Nature Materials·Dongwon LeeNiren Murthy
Jul 25, 2008·Nature·Kezhong Zhang, Randal J Kaufman
Sep 15, 2010·Nature Reviews. Clinical Oncology·Rakesh K Jain, Triantafyllos Stylianopoulos
Dec 13, 2012·Nature Communications·Kenta SaitoTakeharu Nagai

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Citations

Jan 26, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Junjie LiZhishen Ge
Mar 12, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hattie C SchunkLaura J Suggs
Feb 18, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Ajay SinghParas N Prasad

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