Biologic activity and plasma clearance of prolactin-IgG complex in patients with systemic lupus erythematosus

Arthritis and Rheumatism
Alfredo Leaños-MirandaF Blanco-Favela

Abstract

To characterize the clinical findings in hyperprolactinemic systemic lupus erythematosus (SLE) patients with or without macroprolactinemia (big, big prolactin [PRL]) due to anti-PRL autoantibodies (PRL-IgG complex), and to assess the bioactivity and structure of big, big PRL. Twenty-seven SLE patients with hyperprolactinemia (HPRL) were studied. Patients with (n = 8) or without (n = 19) big, big PRL were identified by gel filtration chromatography and affinity chromatography for IgG. PRL concentrations in serum and fractions by gel filtration chromatography and affinity chromatography were characterized by immunoradiometric assay (IRMA), Nb2 bioassay, sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting, and clearance studies. SLE patients without big, big PRL had significantly higher levels of disease activity, cause-proven HPRL, and menstrual disturbances compared with patients with big, big PRL (P < or = 0.05). The big, big PRL fractions by Western blotting revealed a single 23-kd nonglycosylated PRL. The Nb2:IRMA ratio of the samples with big, big PRL was significantly higher than that of the samples without big, big PRL (P < or = 0.02). However, bioactivity of big, big PRL in the Nb2 cells was ver...Continue Reading

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Citations

Apr 21, 2006·Rheumatology International·Zahra Rezaieyazdi, Afsane Hesamifard
Feb 3, 2011·Clinical Reviews in Allergy & Immunology·Hedi OrbachYehuda Shoenfeld
Jun 10, 2005·Clinical Endocrinology·James GibneyT Joseph McKenna
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Jun 15, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Elena PeevaBetty Diamond
Aug 3, 2005·Immunology Letters·Elena Peeva, Moncef Zouali
Nov 28, 2001·Lupus·F Blanco-FavelaA Leaños-Miranda
Feb 5, 2008·Journal of Mammary Gland Biology and Neoplasia·Shelley S Tworoger, Susan E Hankinson
Nov 17, 2009·Clinical Reviews in Allergy & Immunology·Luis J JaraCarmen Navarro
Jan 13, 2006·Clinical Rheumatology·Margaret LiElena Peeva

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