Biologic and immunomodulatory properties of mesenchymal stromal cells derived from human pancreatic islets.

Cytotherapy
Jaehyup KimPeiman Hematti

Abstract

Mesenchymal stromal cells (MSC) have now been shown to reside in numerous tissues throughout the body, including the pancreas. Ex vivo culture-expanded MSC derived from many tissues display important interactions with different types of immune cells in vitro and potentially play a significant role in tissue homeostasis in vivo. In this study, we investigated the biologic and immunomodulatory properties of human pancreatic islet-derived MSC. We culture-expanded MSC from cadaveric human pancreatic islets and characterized them using flow cytometry, differentiation assays and nuclear magnetic resonance-based metabolomics. We also investigated the immunologic properties of pancreatic islet-derived MSC compared with bone marrow (BM) MSC. Pancreatic islet and BM-derived MSC expressed the same cell-surface markers by flow cytometry, and both could differentiate into bone, fat and cartilage. Metabolomics analysis of MSC from BM and pancreatic islets also showed a similar set of metabolic markers but quantitative polymerase chain reactions showed that pancreatic islet MSC expressed more interleukin(IL)-1b, IL-6, STAT3 and FGF9 compared with BM MSC, and less IL-10. However, similar to BM MSC, pancreatic islet MSC were able to suppress pr...Continue Reading

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Dec 29, 2013·Journal of Extracellular Vesicles·Soon Sim TanSai Kiang Lim
Oct 11, 2014·The International Journal of Biochemistry & Cell Biology·Stuart HodgettsPilar Blancafort
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Mar 8, 2021·Free Radical Biology & Medicine·Ryan A Denu, Peiman Hematti
Jun 5, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Michael Nguyen-TruongZhijie Wang

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