Biologic correlates of ¹⁸F-FDG uptake on PET in pulmonary pleomorphic carcinoma

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Kyoichi KairaNobuyuki Yamamoto

Abstract

Pulmonary pleomorphic carcinoma is a rare epithelial tumor, and little is also known about the information on the usefulness of 2-[¹⁸F]-fluoro-2-deoxy-d-glucose (¹⁸F-FDG) positron emission tomography (PET). Therefore, we conducted the study including the underlying biologic analysis of ¹⁸F-FDG uptake. Fifteen patients with pulmonary pleomorphic carcinoma who underwent ¹⁸F-FDG PET before treatment were included in this study. Tumor sections were stained by immunohistochemistry for glucose transporter 1 (Glut1); glucose transporter 3 (Glut3); hypoxia-inducible factor-1 alpha (HIF-1α); cell proliferation (Ki-67 labeling index); vascular endothelial growth factor (VEGF); microvessels (CD34); cell cycle control marker (p53); and apoptosis marker (bcl-2). These parameters were correlated with a control group of patients with other non-small cell lung cancer (NSCLC) (n=33). The maximal standardized uptake value (SUV(max)) of the primary tumors in 15 patients ranged from 6.1 to 26.8 (median 19.3). There were positive correlation between ¹⁸F-FDG uptake and Glut1 (p=0.0016), Glut3 (p=0.0080), VEGF (p=0.0048), and microvessel density (MVD) (p=0.0005). HIF-1α, p53 and bcl-2 showed no positive correlation with ¹⁸F-FDG uptake. ¹⁸F-FDG uptake...Continue Reading

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Citations

Oct 4, 2013·World Journal of Surgical Oncology·Si-Yuan HuangXing-Ya Li
Jan 19, 2016·Annales de pathologie·Martine AntoineMarie Wislez
Jul 10, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Thibault VieiraMarie Wislez
Sep 25, 2016·Annals of Nuclear Medicine·Kotaro HigashiHisao Tonami
Jun 5, 2020·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Yoshihito IijimaTomomi Hirata
Jun 20, 2020·Acta Radiologica·Alexey SurovAndreas Wienke
Oct 10, 2014·Molecular Cancer Therapeutics·Hiromi Kataoka, Mamoru Tanaka
Apr 12, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kayvan R KeshariDavid M Wilson
Jun 11, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G D Di StasioC M Grana

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