Biologic correlation of 2-[18F]-fluoro-2-deoxy-D-glucose uptake on positron emission tomography in thymic epithelial tumors

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Kyoichi KairaNobuyuki Yamamoto

Abstract

The usefulness of 2-[(18)F]-fluoro-2-deoxy-D-glucose ([(18)F]FDG) positron emission tomography (PET) can help predict the grade of malignancy and staging in thymic epithelial tumors. However, no satisfactory biologic explanation exists for this phenomenon. The aim of this study was to investigate the underlying biologic mechanisms of [(18)F]FDG uptake. Forty-nine patients with thymic epithelial tumors who underwent [(18)F]FDG PET were included in this study. Tumor sections were stained by immunohistochemistry for glucose transporter 1 (GLUT1), glucose transporter 3 (GLUT3), hypoxia-inducible factor-1 alpha (HIF-1alpha), vascular endothelial growth factor (VEGF), microvessels (CD31 and CD34), cell cycle control marker (p53), and apoptosis marker (bcl-2). We also conducted an in vitro study of [(18)F]FDG uptake in a thymic tumor cell line. There was a positive correlation between [(18)F]FDG uptake and GLUT1 (P < .0001), HIF-1alpha (P = .0036), VEGF (P < .0001), microvessel density (MVD; P < .0001), and p53 (P = .0002). GLUT3 and bcl-2 showed no positive correlation with [(18)F]FDG uptake. The expression of Glut1, HIF-1alpha, VEGF, CD31, CD34, and p53 was also significantly associated with the grade of malignancy and poor outcome ...Continue Reading

References

Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Jul 16, 1990·Biochemical and Biophysical Research Communications·T YamamotoH Imura
Apr 27, 1972·The New England Journal of Medicine·K J Isselbacher
Feb 1, 1994·European Journal of Biochemistry·M Mueckler
Apr 1, 1996·British Journal of Cancer·K KubotaT Ido
Jun 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J F VansteenkisteM G Demedts
Jul 27, 2000·The New England Journal of Medicine·R M PietermanH J Groen
Feb 7, 2002·The European Respiratory Journal·E BrambillaY Shimosato
Aug 31, 2002·The Journal of Thoracic and Cardiovascular Surgery·Masaki TomitaToshio Onitsuka
Dec 14, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kenzo HiroshimaHidemi Ohwada
Apr 25, 2003·International Journal of Cancer. Journal International Du Cancer·Eric A Engels, Ruth M Pfeiffer
Jun 20, 2003·The New England Journal of Medicine·Didier LardinoisHans C Steinert
Dec 13, 2005·Nature Medicine·George V ThomasCharles L Sawyers
Feb 13, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Hatem El-BawabKhaled Al-Kattan
Feb 27, 2007·Free Radical Biology & Medicine·Margret C M VissersMargaret J Currie
May 4, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christopher C RiedlYuman Fong
May 22, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Angela van BaardwijkDirk De Ruysscher
Nov 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marie E GibbsRoger J Summers
Feb 29, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Masahiro EndoToru Kameya
Dec 10, 2008·International Journal of Cancer. Journal International Du Cancer·Kyoichi KairaMasatomo Mori
Jan 22, 2009·The Journal of Thoracic and Cardiovascular Surgery·Matthew D TaylorDavid R Jones
May 22, 2009·Oral Oncology·So Young MoonSang Yoon Kim
Jul 7, 2009·The Journal of Thoracic and Cardiovascular Surgery·Tommaso C MineoDavide Mineo
Jul 9, 2009·Annals of Nuclear Medicine·Arvind KumarTarun Jindal
Aug 4, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Masakazu KojikaAtsushi Ochiai
Dec 1, 2000·European Journal of Nuclear Medicine·K HigashiI Yamamoto

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Citations

Jun 27, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Aiko NobusawaTetsunari Oyama
Feb 24, 2012·International Journal of Clinical Oncology·Kyoichi KairaNobuyuki Yamamoto
Oct 4, 2011·Pathology Oncology Research : POR·Kyoichi KairaNobuyuki Yamamoto
Dec 26, 2012·Biochimica Et Biophysica Acta·Leszek Szablewski
Jun 9, 2015·PET Clinics·Mie Holm Vilstrup, Drew A Torigian
Feb 6, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anish ThomasGiuseppe Giaccone
Mar 1, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Marcelo F K BenvenisteEdith M Marom
Apr 12, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Alexander MarxWilliam D Travis
Feb 4, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kyoichi KairaNobuyuki Yamamoto
Dec 30, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tomonari KinoshitaHisao Asamura
Nov 5, 2015·Pathology, Research and Practice·Vincent Thomas de MontprévilleThierry Jo Molina
Nov 26, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Akira ShimizuOsamu Ishikawa
Dec 10, 2013·General Thoracic and Cardiovascular Surgery·Chihiro YamataniHaruhiko Kondo
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N GirardUNKNOWN ESMO Guidelines Committee
Feb 15, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kyoichi KairaNobuyuki Yamamoto
May 10, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kyoichi KairaNobuyuki Yamamoto
Nov 8, 2011·European Journal of Radiology·Kyoichi KairaNobuyuki Yamamoto
Mar 6, 2015·Acta Oto-laryngologica·Yuki YokoboriKazuaki Chikamatsu
Sep 15, 2015·Surgical Case Reports·Fumihiro IshibashiToshihiko Iizasa
Oct 6, 2012·The Journal of Medical Investigation : JMI·Hideki Otsuka
Apr 29, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Hideki SuzukiHiroyuki Kuwano
Dec 25, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kyoichi KairaNobuyuki Yamamoto
Jun 9, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Rossano LattanzioMassimo Rinaldi
Sep 2, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Giorgio TregliaFilippo Lococo
Jul 30, 2016·Frontiers in Oncology·Natalie J Serkova, S Gail Eckhardt
Aug 10, 2016·Pathology Oncology Research : POR·Akira ShimizuOsamu Ishikawa
Sep 27, 2016·European Journal of Radiology·Hayato KaidaMasatoshi Ishibashi
Aug 23, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Kyoichi KairaTakayuki Asao
Feb 5, 2013·Acta Radiologica·Punit SharmaRakesh Kumar

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