PMID: 8453550Apr 1, 1993Paper

Biologic distinctions between cure and time to death in 2892 patients with intraocular melanoma

Cancer
J W GamelJ McCurdy

Abstract

For certain types of cancer, resection alone rarely achieves a cure, but patients nevertheless tend to have a prolonged survival before they die of the tumor. For other types of cancer, the opposite scenario prevails, suggesting that those biologic mechanisms that allow a curative resection are not identical to those that determine survival time among uncured patients. The multivariate log-normal model can be used to detect the association of cured fraction and median survival time of patients with specific prognostic covariates. This model was applied to survival data from 2892 patients with intraocular melanoma who were treated by enucleation. This analysis showed that large tumor size and pleomorphic nucleoli within the tumor were associated independently with a low probability of cure and short median survival time. Advanced patient age and mixed cell type, however, were highly associated with only a short median survival time. For patients with intraocular melanoma treated only by enucleation, the median survival time is not modulated by the same biologic factors that determine the likelihood of a curative resection.

Citations

Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·I W McLean
May 21, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·I W ReinigerA J Mueller
Oct 16, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Edoardo MidenaStela Vujosevic
Jul 27, 2007·Clinical & Experimental Metastasis·Adriana AlbiniDouglas M Noonan
Nov 1, 1996·Survey of Ophthalmology·C M Mooy, P T De Jong
Nov 1, 1995·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·M G Fleming
Feb 1, 1995·The British Journal of Ophthalmology·C MooyF Bosman
Jan 1, 1997·Cancer Investigation·T SatoM J Mastrangelo
Jan 1, 1995·The Journal of Pathology·T J De VriesG N Van Muijen
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Pieter A van der VeldenNelleke A Gruis
Jul 19, 2005·Ophthalmology·Igor KaisermanJacob Pe'er
Apr 2, 2015·Indian Journal of Ophthalmology·Swathi KalikiJerry A Shields
Aug 16, 2016·Veterinary Ophthalmology·Amanda B ShermanBrian C Gilger
Nov 10, 2007·Melanoma Research·Wieke ZuidervaartNicholas K Hayward
Oct 11, 2002·Statistics in Medicine·Paul Frankel, Jeffrey Longmate
Apr 16, 2015·Vestnik oftalmologii·A G Amiryan, S V Saakyan
Jun 1, 2018·Oncology and Therapy·Manni SinghJensen Yeung
Apr 15, 2021·Progress in Retinal and Eye Research·Thomas StrubCorine Bertolotto
Dec 7, 2010·Archives of Pathology & Laboratory Medicine·Nora V LaverJay S Duker
Oct 7, 2005·Journal français d'ophtalmologie·F MouriauxF Mascarelli
May 3, 2019·Ocular Oncology and Pathology·Caroline BailyNoel Horgan

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