Biologic effects of bacterial superantigens in a xenogeneic transplantation model for psoriasis

The Journal of Investigative Dermatology. Symposium Proceedings
W H Boehncke

Abstract

Both clinical as well as experimental data support the concept of psoriasis being a T-cell-mediated immune disease possibly triggered by bacterial superantigens. Further analysis of its pathogenesis was facilitated by the generation of a xenogeneic transplantation model in which skin from psoriatic patients is grafted onto SCID mice lacking functional B and T cells. Applying this model it was demonstrated that psoriasis can be triggered by bacterial superantigens; this process depends on the presence of immunocytes. Mutated variants of the respective superantigens exhibiting no measurable affinity to HLA class II molecules can function as competitive inhibitors in vivo.

References

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Apr 9, 1999·Archives of Dermatological Research·W H BoehnckeR Kaufmann
Sep 11, 1999·Archives of Dermatological Research·W H Boehncke

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Citations

Sep 13, 2008·The Journal of Investigative Dermatology·Richard S KalishAmos Gilhar
Apr 17, 2007·Journal of the American Academy of Dermatology·Hilal Maradit KremersSherine E Gabriel
May 30, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Sebastian HaidarliuEhud Ahissar

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