Biologic failure of a ligament advanced reinforcement system artificial ligament in anterior cruciate ligament reconstruction: a report of serious knee synovitis

Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Hong LiShiyi Chen

Abstract

A ligament advanced reinforcement system (LARS) artificial ligament has been proposed for use in anterior cruciate ligament reconstruction in some cases, and an emerging body of reports has shown its success in the short term. However, there are great concerns about the potential risks of complications, which might prevent its extensive use. We report a rare case of serious synovitis 3 years postoperatively in a 26-year-old man who underwent LARS artificial ligament reconstruction. During revision arthroscopy, we observed a large amount of synovial hyperplasia in the knee joint, containing a large amount of hemosiderin deposition. In addition, the femoral tunnel was placed too anteriorly, and the ligament was ruptured near the tibial tunnel. Histologically, there was thick fibrous scar tissue around the graft, and poorly organized fibrous scar tissue infiltrated into the graft fibers, which could cause loss of structural integrity of the ligament and eventual graft failure. Collectively, our findings might arouse further in-depth research on the development of artificial ligament.

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Citations

Jun 4, 2013·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Véronique ViateauVéronique Migonney
Apr 3, 2012·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·James H LubowitzGary G Poehling
May 16, 2014·Journal of Biomedical Materials Research. Part a·Hong Li, Shiyi Chen
May 9, 2015·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·James H Lubowitz
Jan 27, 2015·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·MaCalus V HoganFreddie H Fu
Apr 11, 2018·The Physician and Sportsmedicine·Alex C DiBartolaDavid C Flanigan
Nov 9, 2018·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Scott John TullochChris Mow
Feb 5, 2015·Annals of Biomedical Engineering·Anthony RatcliffeEvan L Flatow
Apr 8, 2019·ACS Biomaterials Science & Engineering·Jianjun YangShiyi Chen
Nov 13, 2021·Biomaterials Science·Shreyasi MajumdarSairam Krishnamurthy

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