Biologic-free mechanically induced muscle regeneration

Proceedings of the National Academy of Sciences of the United States of America
Christine A CezarDavid J Mooney

Abstract

Severe skeletal muscle injuries are common and can lead to extensive fibrosis, scarring, and loss of function. Clinically, no therapeutic intervention exists that allows for a full functional restoration. As a result, both drug and cellular therapies are being widely investigated for treatment of muscle injury. Because muscle is known to respond to mechanical loading, we investigated instead whether a material system capable of massage-like compressions could promote regeneration. Magnetic actuation of biphasic ferrogel scaffolds implanted at the site of muscle injury resulted in uniform cyclic compressions that led to reduced fibrous capsule formation around the implant, as well as reduced fibrosis and inflammation in the injured muscle. In contrast, no significant effect of ferrogel actuation on muscle vascularization or perfusion was found. Strikingly, ferrogel-driven mechanical compressions led to enhanced muscle regeneration and a ∼threefold increase in maximum contractile force of the treated muscle at 2 wk compared with no-treatment controls. Although this study focuses on the repair of severely injured skeletal muscle, magnetically stimulated bioagent-free ferrogels may find broad utility in the field of regenerative me...Continue Reading

References

Jan 19, 1979·Science·H Vandenburgh, S Kaufman
Jul 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·H H Vandenburgh, P Karlisch
Jan 23, 1999·Biomaterials·J A RowleyD J Mooney
Jun 20, 2001·Experimental Cell Research·R TatsumiR E Allen
Jul 18, 2001·Journal of Applied Physiology·T J Hawke, D J Garry
Oct 10, 2002·American Journal of Physiology. Cell Physiology·Courtney A PowellHerman H Vandenburgh
Aug 9, 2003·International Journal of Sports Medicine·B DrustD Binningsley
Sep 17, 2004·American Journal of Physiology. Cell Physiology·Troy A HornbergerKaryn A Esser
Feb 26, 2005·Sports Medicine·Pornratshanee WeerapongGregory S Kolt
Apr 27, 2005·The American Journal of Sports Medicine·Tero A H JärvinenMarkku Järvinen
Jun 9, 2006·In Vitro Cellular & Developmental Biology. Animal·Lisa M LarkinJeffrey B Kennedy
Jan 19, 2007·Journal of Thrombosis and Haemostasis : JTH·E A Silva, D J Mooney
Feb 1, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura PelosiAntonio Musarò
Jul 24, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ruth R ChenDavid J Mooney
Aug 19, 2007·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Dario ColettiSergio Adamo
Nov 22, 2007·PloS One·Takuya MatsumotoTaiji Sohmura
Dec 29, 2007·Seminars in Immunology·James M AndersonDavid T Chang
Apr 11, 2008·Tissue Engineering. Part a·Du Geon MoonJames J Yoo
Jun 27, 2008·Medicine and Science in Sports and Exercise·Timothy A ButterfieldThomas M Best
Nov 1, 2008·Journal of Applied Physiology·Jennifer M Peterson, Francis X Pizza
Dec 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Cristina BorselliDavid J Mooney
Mar 17, 2010·Journal of Cellular Physiology·Roel W Ten BroekJohannes W Von den Hoff
Oct 22, 2010·Pediatric Transplantation·Beniamino PalmieriLodi Daniele
Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Xuanhe ZhaoDavid J Mooney
Jan 5, 2011·Organogenesis·Carlo Alberto RossiPaolo De Coppi
Jun 15, 2011·Cell and Tissue Research·Neill J Turner, Stephen F Badylak
Sep 1, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jacob KofflerShulamit Levenberg
Jan 4, 2012·Bioelectromagnetics·Tomonori SakuraiJunji Miyakoshi
Feb 4, 2012·Science Translational Medicine·Justin D CraneMark A Tarnopolsky
Aug 25, 2012·Current Opinion in Neurology·Francesco S Tedesco, Giulio Cossu
Jan 1, 2013·Medicine and Science in Sports and Exercise·Caroline HaasThomas M Best
May 29, 2013·Current Opinion in Biotechnology·Mark Juhas, Nenad Bursac
Sep 18, 2013·Biomaterials·Yuya MorimotoShoji Takeuchi
Apr 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yulia ShandalovShulamit Levenberg
Apr 29, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Lin WangHerman Vandenburgh
Apr 29, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Dmitry ShvartsmanDavid J Mooney
May 28, 2014·Advanced Healthcare Materials·Christine A CezarDavid J Mooney

❮ Previous
Next ❯

Citations

Jul 5, 2016·Journal of Biomedical Materials Research. Part a·Homero F PastranaJean Paul Allain
Jul 26, 2016·Journal of Experimental Orthopaedics·Thomas Laumonier, Jacques Menetrey
Aug 30, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberta VisoneMatteo Moretti
Dec 23, 2016·Scientific Reports·Christine NardiniJennifer E Dent
Mar 28, 2017·Tissue Engineering. Part a·Jenna L DzikiStephen F Badylak
May 2, 2017·Tissue Engineering. Part B, Reviews·Manuela E GomesRui L Reis
May 10, 2018·Journal of Cellular Physiology·Tamagno PesqueiraManuela E Gomes
Oct 7, 2016·Physical Chemistry Chemical Physics : PCCP·Peet CremerAndreas M Menzel
Nov 9, 2017·Nature Reviews. Molecular Cell Biology·Kyle H Vining, David J Mooney
May 26, 2018·Biomedical Materials·Ana I GonçalvesManuela E Gomes
Oct 5, 2018·Chemical Society Reviews·Wen LiXiaogang Qu
Feb 5, 2019·Lab on a Chip·Berna ÖzkaleMahmut Selman Sakar
Feb 7, 2019·Advanced Healthcare Materials·Karina H NakayamaNgan F Huang
Mar 18, 2016·Annals of Biomedical Engineering·Akhil PatelShilpa Sant
Jun 13, 2019·Birth Defects Research·Dana D Damian
Jul 31, 2019·Chemical Communications : Chem Comm·Fangli GangXiaodan Sun
Oct 28, 2016·The Journal of Trauma and Acute Care Surgery·David CholokBenjamin Levi
Aug 26, 2020·Chemical Communications : Chem Comm·Saurabh JoshiSuresh Valiyaveettil
Jul 30, 2019·Science Advances·S O BlacklowD J Mooney
Mar 27, 2020·Frontiers in Chemistry·Zhongyang LiuPeifu Tang
Dec 28, 2017·Advanced Healthcare Materials·Vanessa Fernandes CardosoSenentxu Lanceros-Mendez
Mar 15, 2018·Current Osteoporosis Reports·Claudia SchlundtKatharina Schmidt-Bleek
May 15, 2019·Journal of Orthopaedic Trauma·Brett D CristMark A Lee
Feb 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tamagno PesqueiraAnthony S Weiss
Feb 28, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jingda TangTiejun Wang
Oct 3, 2018·Proceedings of the National Academy of Sciences of the United States of America·Theresa M Raimondo, David J Mooney
Aug 9, 2019·Science Advances·Brian J KweeDavid J Mooney
Aug 24, 2019·Cells·Tzyy-Yue WongPei-Wen Cheng
May 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jingda TangT J Wang
Jan 17, 2021·Developmental Cell·Sudong KimChristopher S Chen
Nov 1, 2020·Biomaterials·Berna ÖzkaleDavid J Mooney
Jan 10, 2018·Science Robotics·Dana D DamianPierre E Dupont
Aug 28, 2019·Science Robotics·E B DolanE T Roche
Jan 21, 2021·Acta Biomaterialia·Shengyong Ng, Motoichi Kurisawa
Mar 2, 2021·Advanced Healthcare Materials·Jacob P QuintAli Tamayol
Feb 9, 2018·Biomaterials·Stephen KennedyDavid Mooney
Jun 20, 2018·Biomaterials·Brian J KweeDavid J Mooney
Mar 16, 2021·Exercise and Sport Sciences Reviews·Douglas W Van PeltEsther E Dupont-Versteegden

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.