Biologic glue increases capillary ingrowth after cardiomyoplasty in an ischemic cardiomyopathy model

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
V S ChekanovP I Lelkes

Abstract

The authors investigated the multi-step mechanism of healing after cardiomyoplasty, focusing on the process of angiogenesis. The authors contend that enhancement of angiogenesis and prevention of ischemia-reperfusion injuries immediately after muscle mobilization will be effective in improving cardiomyoplasty results. After cardiomyoplasty, autologous biologic glue (ABG) was administered between the latissimus dorsi muscle (LDM) and myocardium. By 2 months, a new pseudo interlayer was present that bridged the gap between the LDM and myocardium. Neovascularization was visible in the form of numerous small capillaries. Marked degeneration of the LDM was noted, possibly caused by muscle ischemia-reperfusion damage after mobilization. Pockets were created of ischemic and nonischemic LDM to test for angiogenesis. One was left free of ABG (control); one received ABG only; one received ABG and pyrrolostatin. Some of the capillaries were large and had erythrocytes inside. biopsy samples showed 9.4 +/- 1.9% of the sample was occupied by blood vessels (compared with 3.6 +/- 0.7% in control muscle). These preliminary studies prove the feasibility of the authors' concept and provide evidence that angiogenesis can accelerate the healing pro...Continue Reading

Citations

Nov 25, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Andreas H ZischJeffrey A Hubbell
Jul 19, 2006·Tissue Engineering·Seung-Woo ChoByung-Soo Kim
Mar 20, 2003·Journal of Cardiac Surgery·Valeri S ChekanovMasood Akhtar
Mar 16, 2000·Artificial Organs·V V NikolaychikP I Lelkes
Jun 23, 2006·Clinical and Experimental Pharmacology & Physiology·Chun-Ling FanDing-Liang Zhu
May 17, 2005·Journal of the American College of Cardiology·Valeri ChekanovVictor Nikolaychik
May 29, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·V S ChekanovV V Nikolaychik
Apr 12, 2003·Pacing and Clinical Electrophysiology : PACE·Valeri ChekanovNicholas N Kipshidze

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