PMID: 2120848Oct 1, 1990Paper

Biologic heterogeneity of human immunodeficiency virus type 2 (HIV-2) strains

Virology
B A CastroJ A Levy

Abstract

Seven HIV-2 isolates recovered from peripheral blood mononuclear cells (PBMC) of patients from the Ivory Coast have been biologically characterized. All seven strains replicated well in primary human lymphocyte and macrophage cultures and in established human T cell lines. They showed differences in infectivity and replicating ability in primary PBMC cultures from chimpanzees, rhesus macaques, and baboons. Moreover, variations in levels of virus replication in PBMC from 13 seronegative donors were observed. Four strains (UC2, UC3, UC7, and UC8) were highly cytopathic and caused extensive surface CD4 antigen depletion in acutely infected PBMC and SupT1 cells. Two strains (UC1 and UC6) showed minimal or no cytopathology, no CD4 down-modulation, and much lower levels of virus protein expression in SupT1 cells. These findings reflect the heterogeneity of HIV-2 strains and suggest that these biological properties could influence pathogenesis in the host.

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Citations

Jul 1, 1994·Immunology Today·D Mosier, H Sieburg
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M Le Guern, J A Levy
Feb 13, 2003·AIDS Research and Human Retroviruses·Christopher P LocherJay A Levy
Feb 7, 1998·AIDS Research and Human Retroviruses·C P LocherJ A Levy
Jul 2, 2005·AIDS Research and Human Retroviruses·Mayur TamhaneRobin Mukhopadhyaya
Feb 24, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·M CucchiariniA Doglio
Jul 30, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ae S YoungpairojS Michele Owen
Jan 6, 2010·Reviews in Medical Virology·Emi E Nakayama, Tatsuo Shioda
Sep 16, 2015·AIDS·Emi E Nakayama, Tatsuo Shioda
Jul 4, 2006·Virology·Hetty BlaakAlbert D M E Osterhaus
Feb 10, 2009·Virus Research·Q Santos-CostaJ M Azevedo-Pereira
Nov 6, 2009·Dermatologic Therapy·Natalia MendozaStephen Tyring
Jan 10, 2003·Journal of Medical Primatology·C P LocherS A Johnston
Feb 1, 1996·Biological Chemistry Hoppe-Seyler·Y M HenskensA V Nieuw Amerongen
Sep 1, 1992·Journal of Virology·R E UngerP A Luciw
Mar 1, 1993·Microbiological Reviews·J A Levy

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