PMID: 6977405Feb 1, 1982Paper

Biologic markers and breast cancer: a multiparametric study--1. Increased serum protein levels

Cancer
G LamoureuxR Jolicoeur

Abstract

From early 1972 to the end of 1976, the profiles of several serum protein were used to monitor disease stage and prognosis of 207 patients with breast cancer. Six of these proteins, alpha 1-antitrypsin (alpha-AT), alpha 2-ceruloplasmin (Cp), beta 1-transferrin, IgA, C4, and C5, were significantly elevated in these cancer patients and were used as biologic markers in a multiparametric study. Among these breast cancer patients, 72% had at least two of these protein levels elevated, of which alpha-AT (55%), C5 (38%), and IgA (36%) levels were most commonly raised. The number of elevated proteins was parallel to disease progression as 61% (Group 1) and 74% (Group 2) of the patients with operable breast cancer and 90% of patients with metastatic disease showed an elevation of two or more of these nonspecific proteins. There was also a positive correlation between the number of elevated proteins and prognosis; of the 26 patients who died during the five-year follow-up, only four (15%) had no more than one protein level elevated, and 22 (85%) had two or more protein levels elevated. On the other hand, when considered as a group, patients with no or only one protein level elevated had a better prognosis than patients with two or more l...Continue Reading

References

Jan 1, 1975·International Archives of Allergy and Applied Immunology·C C Bernard, G Lamoureux
Jan 1, 1976·Annals of Clinical Biochemistry·A M Neville, E H Cooper
Jan 1, 1978·Antibiotics and Chemotherapy·P F ZangerleP Franchimont
Mar 25, 1978·Lancet·K HöffkenR W Blamey
May 1, 1978·British Journal of Cancer·D M ThomsonP Gold
Oct 1, 1977·The Australian and New Zealand Journal of Surgery·B N GrayR C Bennett
Oct 1, 1977·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R L WoodsE H Cooper
Nov 1, 1977·Journal of Clinical Pathology·K W Pettingale, D E Tee
Sep 15, 1976·International Journal of Cancer. Journal International Du Cancer·A J CochranA M Jackson
Apr 1, 1977·British Journal of Cancer·M MunzarovàA Malìr
May 1, 1977·Cancer·D Y WangJ L Hayward
Aug 1, 1977·Cancer·R C CoombesA M Neville
Oct 1, 1975·The British Journal of Surgery·J G RobertsM Baum
Jul 1, 1973·Cellular Immunology·D R BurgerR M Vetto
Jan 1, 1973·Scandinavian Journal of Immunology·H HedbergO Nilsson
Apr 1, 1973·The Australian Journal of Experimental Biology and Medical Science·D S Nelson, J M Penrose
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Oct 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·S Snyder, G Ashwell
Jan 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·J Hájek

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Citations

Jan 1, 1991·Cancer Immunology, Immunotherapy : CII·J F RobertsonA Howell
Nov 15, 1990·Clinica Chimica Acta; International Journal of Clinical Chemistry·R TroccoliF Mannello
Jan 30, 1994·Cancer Letters·F MannelloG Gazzanelli
May 7, 1998·Cancer Letters·A Senra VarelaD Quintela Senra
Feb 1, 1986·Clinical Otolaryngology and Allied Sciences·C Suarez NietoC Alvarez Marcos
Aug 22, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·M KailajärviK Irjala
Oct 1, 1992·Journal of Neurosurgery·I S VaithilingamR F Del Maestro
Jan 1, 1984·Journal of Clinical Pathology·R RossielloG G Giordano
Jan 4, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anders CarlssonCarl A K Borrebaeck
Jan 20, 2010·Biotechnology Journal·Rod A HermanMark Krieger
Feb 1, 1984·European Journal of Cancer & Clinical Oncology·A VasishtaA Cuschieri
Dec 15, 1984·International Journal of Cancer. Journal International Du Cancer·J BurchellJ Taylor-Papadimitriou
Sep 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·T PaavonenL C Andersson
Mar 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jami MandelinWadih Arap
Jan 10, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ioannis PeppasMieke Van Hemelrijck

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