PMID: 9185326May 1, 1997Paper

Biological activities of aqueous extracts from marine sponges and cytotoxic effects of 3-alkylpyridinium polymers from Reniera sarai

Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology
Kristina SepcićTom Turk

Abstract

We screened the biological activity of 21 marine sponges collected in the northern Adriatic sea. Hemolytic, hemagglutinating, antimicrobial, cytotoxic, and anti-acetilcholinesterase activities of the extracts were monitored. We found that hemolytic activity was generally weak; only extracts from three sponge species possess considerable activity. Hemagglutinating activity was present in almost half of extracts but with little specificity against human erythrocytes of different blood groups. Detectable antimicrobial activity was present in only two extracts, while most of them possessed cytotoxic activity. Strong anti-cholinesterase activity was present only in one sample. 3-alkypyridinium polymers isolated from Reniera sarai were hemolytic and strongly cytotoxic against different cell lines with slightly expressed specificity against transformed cells.

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Citations

Feb 18, 2011·Journal of Chemical Biology·Wael E HoussenMarcel Jaspars
Jan 11, 2000·International Journal of Biological Macromolecules·K SepcićP Macek
Jan 6, 2000·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·P MalovrhP Macek
Mar 15, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Iwan PalmerSusan A Clarke
Jul 7, 2009·Journal of Hazardous Materials·Janez ValantRok Kostanjsek
Jun 18, 2014·Journal de mycologie médicale·M NazemiO Ahmadzadeh
Aug 1, 2012·Toxicon : Official Journal of the International Society on Toxinology·Mojca LunderLovro Ziberna
Sep 9, 2010·Marine Pollution Bulletin·Josep Lloret
Dec 25, 2010·Biofouling·Daniela BlihogheAngelo Fontana
Jan 12, 2021·Applied Physics. A, Materials Science & Processing·Liubov MuzychkaHermann Ehrlich

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