Biological activities of extracts from Aspidosperma subincanum Mart. and in silico prediction for inhibition of acetylcholinesterase

Phytotherapy Research : PTR
Marina Pereira RochaCláudia Gontijo Silva

Abstract

Species of Aspidosperma are traditionally used to treat malaria, leishmaniasis, microbial, and inflammatory diseases. Aspidosperma subincanum Mart. known as "guatambu" is used in Brazilian traditional medicine to treat diabetes, hypercholesterolemia, and digestive diseases. Its tonic properties have been employed by the indigenous populations to stimulate the circulatory and genitourinary tracts and to improve respiratory function as well as to relieve spasms and to reduce fever. The species is known to contain antitumoural and antimalarial indole alkaloids. In the present study, various less explored biological activities of extracts from leaves and branches of A. subincanum were investigated, that is, inhibition of acetylcholinesterase as well as antioxidant and antibacterial activity. Twenty-one known indole alkaloids from this species were targeted for predicting the inhibition of acetylcholinesterase, and their biological activities were collected from the literature. Through in silico the prediction, the indole alkaloids uleine and derivatives demonstrated a strong probability of being able to inhibit the acetylcholinesterase enzyme, as well as the olivacine derivatives 3,4-dihydroolivacine and N-methyl-tetrahydro-olivaci...Continue Reading

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Citations

Dec 16, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marina Pereira RochaClaudia Gontijo Silva
Oct 1, 2020·BMC Complementary Medicine and Therapies·Rashid MahmoodFaiza Rasheed
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pedro Cruz-VicenteEugenia Gallardo
Sep 17, 2021·Planta medica·Carolina Reis Cerqueira SudanVera Lúcia de Almeida

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