PMID: 8590636Dec 1, 1995Paper

Biological activities of synthetic analogues of Alternaria alternata toxin (AAL-toxin) and fumonisin in plant and mammalian cell cultures

Phytochemistry
H K AbbasW T Shier

Abstract

In a search for an analogue of AAL-toxin with high phytotoxicity and low mammalian toxicity, aminopentols [(AP1), hexacetyl AP1 and N-acetyl AP1], and nine analogues (1-9), were tested for toxicity to duckweed (Lemna pausicostata), susceptible tomato (asc/asc) leaf discs, black nightshade leaf discs and mammalian cell lines, including dog kidney (MDCK), rat liver hepatoma (H4TG) and mouse fibroblasts (NIH3T3). These were compared with AAL-toxin and fumonisin B1 (FB1). Analogue 9 at 10 microM increased cellular leakage and chlorophyll loss from both tomato and black nightshade leaf discs. The diester 9 was the most active in the duckweed bioassay, but it was much less toxic to MDCK and H4TG cells with an IC50 of 200 microM compared to 10 microM for FB1. Analogue 9 and FB1 showed similar low toxicities (IC50 = 150 microM) to NIH3T3 cells. Among the substances tested, only analogue 9 had significant phytotoxicity and low mammalian toxicity, indicating some potential for development of safe and effective natural herbicides.

References

Feb 1, 1992·Mycopathologia·B M Colvin, L R Harrison
Mar 1, 1992·Carcinogenesis·W C GelderblomE Farber
Mar 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·H K AbbasW T Shier
Mar 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·H K Abbas, R F Vesonder

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Citations

Mar 22, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y Cetin, L B Bullerman
Aug 8, 2002·Toxicon : Official Journal of the International Society on Toxinology·F CaloniI De Angelis
Dec 5, 1998·Toxicon : Official Journal of the International Society on Toxinology·H K AbbasS M Musser
Sep 28, 2002·International Immunopharmacology·Charissa Dresden-Osborne, Gayle Pittman Noblet
Aug 25, 2015·Frontiers in Plant Science·Tünde PusztahelyiIstván Pócsi
Feb 3, 2007·Natural Product Reports·Richard N Strange
May 21, 2016·Frontiers in Microbiology·Ilse VanhoutteLeen De Gelder
Mar 8, 2019·Pest Management Science·Bing ZhouSheng Qiang
Aug 5, 2017·Annual Review of Phytopathology·Gah-Hyun LimPradeep Kachroo
Nov 23, 2018·Progress in Lipid Research·Adiilah Mamode CassimSébastien Mongrand
Apr 30, 2021·Chemico-biological Interactions·Nadeem IqbalAttila Ördög
Aug 4, 2005·Journal of Agricultural and Food Chemistry·Yanet Hernández-RomeroRachel Mata

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