Biological activities of unique isoflavones prepared from Apios americana Medik

Bioscience, Biotechnology, and Biochemistry
Haruna KanetaKazuoshi Shindo

Abstract

Four unique isoflavone aglycones (barpisoflavone A (1), 2'-hydroxygenistein (2), 5-methylgenistein (3), and gerontoisoflavone A (4)) whose structures were related to genistein were prepared from the tuber of Apios americana Medik. We examined the estrogen receptor and androgen receptor binding activities, estrogen agonistic activities, antioxidant activities, and α-glucosidase inhibitory activities of 1-4. The results obtained showed that 2 possessed potent and 1, 3, and 4 possessed moderate estrogen partial agonistic activities, 1 and 2 possessed moderate antioxidant activities, and 2 and 3 possessed moderate α-glucosidase inhibitory activities.

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Citations

Sep 5, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jang Hoon KimChang Hyun Jin
Jan 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jang Hoon KimChang Hyun Jin
May 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andreia S P PereiraZeno Apostolides

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