Biological Activities of Uric Acid in Infection Due to Enteropathogenic and Shiga-Toxigenic Escherichia coli

Infection and Immunity
John K CraneAgnieszka Lis

Abstract

In previous work, we identified xanthine oxidase (XO) as an important enzyme in the interaction between the host and enteropathogenic Escherichia coli(EPEC) and Shiga-toxigenic E. coli(STEC). Many of the biological effects of XO were due to the hydrogen peroxide produced by the enzyme. We wondered, however, if uric acid generated by XO also had biological effects in the gastrointestinal tract. Uric acid triggered inflammatory responses in the gut, including increased submucosal edema and release of extracellular DNA from host cells. While uric acid alone was unable to trigger a chloride secretory response in intestinal monolayers, it did potentiate the secretory response to cyclic AMP agonists. Uric acid crystals were formed in vivo in the lumen of the gut in response to EPEC and STEC infections. While trying to visualize uric acid crystals formed during EPEC and STEC infections, we noticed that uric acid crystals became enmeshed in the neutrophilic extracellular traps (NETs) produced from host cells in response to bacteria in cultured cell systems and in the intestine in vivo Uric acid levels in the gut lumen increased in response to exogenous DNA, and these increases were enhanced by the actions of DNase I. Interestingly, add...Continue Reading

References

Aug 1, 1976·American Journal of Diseases of Children·B S Kaplan, P D Thomson
Jan 20, 1994·Biochemical Pharmacology·T D Nguyen, A T Canada
Jul 1, 1996·The Pediatric Infectious Disease Journal·G PallaA Ventura
Jun 1, 1997·The Journal of Pediatrics·G PallaG Maggiore
Oct 10, 2001·Journal of Bacteriology·S E Finkel, R Kolter
Dec 18, 2001·The Journal of Pediatrics·J M QuanUNKNOWN Pulmozyme Early Intervention Trial Study Group
Jun 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·John K CraneMichael E Duffey
Sep 18, 2002·Antimicrobial Agents and Chemotherapy·John T HancockRoger Harrison
Mar 6, 2004·Science·Volker BrinkmannArturo Zychlinsky
Jan 13, 2006·Nature·Fabio MartinonJürg Tschopp
May 19, 2006·Journal of Bacteriology·Vyacheslav Palchevskiy, Steven E Finkel
May 19, 2006·Journal of Bacteriology·Cristiano G MoreiraVanessa Sperandio
Sep 1, 2007·American Journal of Respiratory and Critical Care Medicine·Patrick A FlumeUNKNOWN Cystic Fibrosis Foundation, Pulmonary Therapies Committee
Nov 6, 2007·Current Opinion in Immunology·Virginie PétrilliJürg Tschopp
Apr 12, 2008·Purinergic Signalling·John K CraneTonniele M Naeher
Mar 3, 2010·Immunological Reviews·Yan ShiGilbert Ng
Jan 1, 2009·Journal of Innate Immunity·Daniela B MunafoSergio D Catz
Apr 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Juan I Fuxman BassAnalía S Trevani
Jul 20, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Akira AshidaHiroshi Tamai
Aug 13, 2011·The New England Journal of Medicine·Najib M RahmanRobert J O Davies
Sep 17, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Taku Morita, Mikiya Fujieda
May 24, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alejandro BalestracciIsmael Toledo
Oct 9, 2012·The Journal of Clinical Investigation·Emily M MallickDavid B Schauer
Dec 13, 2012·Frontiers in Immunology·Christine SchornMartin Herrmann
Dec 26, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·J Michelle KahlenbergMariana J Kaplan
Aug 13, 2013·Periodontology 2000·Paul R CooperIain L C Chapple
Dec 12, 2013·Biochemical and Biophysical Research Communications·Yasuyuki AraiKouhei Yamashita
Jan 1, 2014·Immunological Investigations·John K Crane, Krystin M Mongiardo
Feb 20, 2014·Infection and Immunity·Marc RöhmConstantin F Urban

❮ Previous
Next ❯

Citations

Feb 1, 2018·Nature Reviews. Gastroenterology & Hepatology·Masaki Honda, Paul Kubes
Aug 15, 2020·Molecular Oral Microbiology·Hye-Kyung JunBong-Kyu Choi
Jan 1, 2020·Animal Nutrition·Tolulope O AdebowaleAbimbola O Oso
Apr 21, 2021·Antimicrobial Agents and Chemotherapy·John K CraneMark D Sutton

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Acinetobacter Infections

Acinetobacter infections have become common in hospitalized patients, especially in the intensive care unit setting and are difficult to treat due to their propensity to develop antimicrobial drug resistance. Discover the latest research on Acinetobacter Infections here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.