PMID: 6404176Apr 1, 1983Paper

Biological activity of a growth hormone-releasing factor secreted by a human tumor

The American Journal of Physiology
M J CroninM O Thorner

Abstract

A substance released by a pancreatic islet cell tumor induced signs and symptoms of acromegaly in a young woman. The culture medium in which the tumor was placed after resection was added to rat anterior pituitary cells and incubated in vitro. Both newly synthesized and total rat growth hormone (GH) release as well as cellular cyclic AMP accumulation were stimulated in a dose-dependent manner by the tumor medium. Coincubation with somatostatin blocked these effects. The increase of cyclic AMP preceded the enhanced GH release, indicating that cyclic AMP may be a second messenger for the tumor factor(s). Neither prolactin nor luteinizing hormone secretion was affected by the tumor medium. When measured by a perfused cell column apparatus, there was a rapid and dramatic release of GH by the dispersed rat pituitary cells during a 2.5-, 10-, and 40-min pulse of tumor medium; both the onset and termination of the GH response reached maximal or control values, respectively, within 5 min. Pretreatment of the tumor medium with pepsin markedly attenuated the tumor medium activity, indicating the peptide nature of the factor(s). Finally, ultrastructural analysis indicated that the somatotrophs were degranulated by the tumor medium, wherea...Continue Reading

References

Oct 15, 1976·Science·G BrookerM G Price
Jan 1, 1972·Methods in Enzymology·K WeberM Osborn
Aug 1, 1982·The Journal of Clinical Endocrinology and Metabolism·M J CroninM O Thorner
Apr 1, 1981·Molecular and Cellular Endocrinology·R J Bicknell, J G Schofield
Jan 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H Kuhn
Feb 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·K Hanew, E G Rennels
Apr 1, 1965·Endocrinology·A E JONESW P VANDERLAAN

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