Biological activity of selenorganic compounds at heavy metal salts intoxication

Biomedit︠s︡inskai︠a︡ khimii︠a︡
N Y Rusetskaya, V B Borodulin

Abstract

Possible mechanisms of the antitoxic action of organoselenium compounds in heavy metal poisoning have been considered. Heavy metal toxicity associated with intensification of free radical oxidation, suppression of the antioxidant system, damage to macromolecules, mitochondria and the genetic material can cause apoptotic cell death or the development of carcinogenesis. Organic selenium compounds are effective antioxidants during heavy metal poisoning; they exhibit higher bioavailability in mammals than inorganic ones and they are able to activate antioxidant defense, bind heavy metal ions and reactive oxygen species formed during metal-induced oxidative stress. One of promising organoselenium compounds is diacetophenonyl selenide (DAPS-25), which is characterized by antioxidant and antitoxic activity, under conditions including heavy metal intoxication.

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Citations

Dec 28, 2019·Voprosy kurortologii, fizioterapii, i lechebnoĭ fizicheskoĭ kultury·A V AbramtsovaL E Starokozhko
Jun 4, 2020·Bulletin of Experimental Biology and Medicine·O V Yur'evaS V Balakhonov
Oct 24, 2020·Oxidative Medicine and Cellular Longevity·Tiago E A FrizonJamal Rafique
Jan 10, 2021·Bulletin of Environmental Contamination and Toxicology·Qizhuang LvYulin Zhu

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