Biological activity of terpene compounds produced by biotechnological methods

Pharmaceutical Biology
Roman PaduchJan Fiedurek

Abstract

Biotransformation systems are profitable tools for structural modification of bioactive natural compounds into valuable biologically active terpenoids. This study determines the biological effect of (R)-(+)-limonene and (-)-α-pinene, and their oxygenated derivatives, (a) perillyl alcohol and (S)-(+)- and (R)-(-)-carvone enantiomers and (b) linalool, trans-verbenol and verbenone, respectively, on human colon tumour cells and normal colonic epithelium. Biotransformation procedures and in vitro cell culture tests were used in this work. Cells were incubated for 24 h with terpenes at concentrations of 5-500 μg/mL for NR, MTT, DPPH, and NO assays. IL-6 was determined by ELISA with/without 2 h pre-activation with 10 μg/mL LPS. trans-Verbenol and perillyl alcohol, obtained via biotransformation, produced in vitro effect against tumour cells at lower concentrations (IC50 value = 77.8 and 98.8 μg/mL, respectively) than their monoterpene precursors, (R)-(+)-limonene (IC50 value = 171.4 μg/mL) and (-)-α-pinene (IC50 value = 206.3 μg/mL). They also showed lower cytotoxicity against normal cells (IC50 > 500 and > 200 μg/mL, respectively). (S)-(+)-Carvone was 59.4% and 27.1% more toxic to tumour and normal cells, respectively, than the (R)-(...Continue Reading

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Citations

Feb 12, 2019·Bioscience, Biotechnology, and Biochemistry·Dahu LiHuating Dou
Sep 28, 2018·Scientific Reports·Aitor Hernandez-OrtegaNigel S Scrutton
Jan 6, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alejandra Catalina MollerAlejandro Madrid
Jan 10, 2021·International Journal of Molecular Sciences·Marija IvanovMarina Soković
Jan 12, 2021·Annual Review of Food Science and Technology·Edward J Calabrese
May 4, 2021·Natural Products and Bioprospecting·Suhad A A Al-Salihi, Fabrizio Alberti
May 6, 2021·International Journal of Molecular Sciences·Mariola Zielińska-BłajetJoanna Feder-Kubis

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