PMID: 10867714Jun 27, 2000Paper

Biological and behavioural determinants of the frequency of mild, biochemical hypoglycaemia in patients with Type 1 diabetes on multiple insulin injection therapy

Diabetes/metabolism Research and Reviews
M M JanssenR J Heine

Abstract

Severe hypoglycaemic episodes are an important source of morbidity in people with Type 1 diabetes. The occurrence of severe hypoglycaemia is strongly related to the frequency of low blood glucose readings. The aim of this exploratory study was to identify determinants of the frequency of mild, biochemical hypoglycaemia in patients with Type 1 diabetes treated with multiple insulin injection therapy. We studied 31 patients with Type 1 diabetes in reasonable glycaemic control (HbA(1c)</=8.3%) during multiple injection therapy. The study had a prospective, observational design. We used standardised home blood glucose monitoring (HBGM) diaries to assess the frequency of hypoglycaemia (HBGM readings<3.5 mmol/L) over a period of 6 weeks. Potential determinants studied included biological factors, self-management factors (including weekly total physical activity and vigorous physical activity), psychological factors (including psychological distress) and mediating factors [average and standard deviation (SD) of the HBGM readings and self-reported hypoglycaemia awareness]. Determinants of mild hypoglycaemia frequency identified in univariate regression analyses were: SD and mean of HBGM (beta 0.6, p=0.001 and beta -0.6, p=0.001), diabe...Continue Reading

References

Apr 1, 1991·The American Journal of Clinical Nutrition·E J MayerR F Hamman
Mar 1, 1986·Diabetic Medicine : a Journal of the British Diabetic Association·B ThorsteinssonC Binder
Jan 1, 1985·American Journal of Epidemiology·J F SallisR S Paffenbarger
Sep 26, 1997·The Journal of Clinical Investigation·E FerranniniG Mingrone

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Citations

Sep 22, 2011·Diabetes Technology & Therapeutics·Jaime M Realsen, H Peter Chase
Jun 10, 2009·Circulation·Thomas H MarwickUNKNOWN Interdisciplinary Council on Quality of Care and Outcomes Research
Mar 26, 2004·Research in Nursing & Health·Kayoko InoueAkio Koizumi

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