Biological and chemical study of fused tri- and tetracyclic indazoles and analogues with important antiparasitic activity

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Christian Diaz-UrrutiaJ D Maya

Abstract

A series of fused tri- and tetracyclic indazoles and analogues compounds (NID) with potential antiparasitic effects were studied using voltamperometric and spectroscopic techniques. Nitroanion radicals generated by cyclic voltammetry were characterized by electron spin resonance spectroscopy (ESR) and their spectral lines were explained and analyzed using simulated spectra. In addition, we examined the interaction between radical species generated from nitroindazole derivatives and glutathione (GSH). Biological assays such as activity against Trypanosoma cruzi and cytotoxicity against macrophages were carried out. Finally, spin trapping and molecular modeling studies were also done in order to elucidate the potentials action mechanisms involved in the trypanocidal activity.

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Citations

Apr 5, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eveline M BezerraValder N Freire
Oct 23, 2013·Future Medicinal Chemistry·Benjamín Aguilera-VenegasHernán Speisky
Dec 12, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Fernanda Pérez-CruzClaudio Olea-Azar
Mar 28, 2016·European Journal of Medicinal Chemistry·Cristina Fonseca-BerzalVicente J Arán

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