Biological and clinical implications of HBV infection in peripheral blood mononuclear cells

Autoimmunity Reviews
P PontissoAngelo Gatta

Abstract

The liver is the main site of HBV replication, however extrahepatic organs, such as the lymphoid system, are an important reservoir of the virus. Viral DNA into different mononuclear cell subsets has been mainly detected in monocytes and B lymphocytes. The attachment site of the virus has been identified in the preS1 encoded protein of the virus envelope, the same involved in hepatocyte infection. The risk of HBV transmission by infected lymphocytes has been clearly documented in the setting of liver transplantation where de novo HBV infection has been found in up to about 80% of liver grafts from HBsAg negative but anti-HBc positive donors. In the hemodialysis setting the percentage of HBV DNA detection in mononuclear cells of HBsAg negative patients has been described in up to 54% of the cases. Vertical transmission studies indicate that HBV-infected mononuclear cells of the mother may result in viral infection of mononuclear cells of the newborns and possible HBV vaccine response failure. HBV can also infect bone marrow cells and in vitro studies demonstrate a block of hematopoiesis by HBV, supporting clinical observations of isolate cases of aplastic anemia associated to the infection.

References

Nov 18, 1976·The New England Journal of Medicine·W S Robinson, L I Lutwick
Nov 25, 1976·The New England Journal of Medicine·W S Robinson, L I Lutwick
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J SummersI Millman
Oct 10, 1985·Nature·P TiollaisA Dejean
Aug 1, 1986·The Journal of Clinical Investigation·J B ZeldisR P Gale
Sep 24, 1983·Lancet·J L Romet-LemonneM Essex
May 26, 1984·British Medical Journal·P PontissoC Brechot
Aug 12, 1983·Science·J L Romet-LemonneM Essex
Nov 27, 1993·Lancet·J Y Lau, T L Wright
Jan 1, 1994·The Journal of Clinical Investigation·T I MichalakF V Chisari
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·L V TsuiF V Chisari
Sep 19, 1997·Journal of the American Society of Nephrology : JASN·M CabrerizoV Carreño
Dec 29, 2000·Cellular and Molecular Life Sciences : CMLS·B Liang, M J Mamula
Jun 5, 2001·The Journal of Biological Chemistry·S De FalcoG Fassina
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K KakimiL G Guidotti
Apr 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Stefan WielandFrancis V Chisari

❮ Previous
Next ❯

Citations

Jan 18, 2013·Clinical Reviews in Allergy & Immunology·Mariele GattoAndrea Doria
Jul 27, 2010·Cellular & Molecular Immunology·Lemonica KoumbiVassiliki Papaevangelou
Jan 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Guoxin LiangMasamichi Muramatsu
Jun 3, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Carla S CoffinM John Gill
Jun 2, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Yeo Myeong KimDong Ho Lee
Jun 24, 2010·Pathologie-biologie·Y XieM Zhao
Jun 26, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Philipp A LangKarl S Lang
Sep 16, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Georgina McAllisterRory Gunson
Feb 11, 2016·Jundishapur Journal of Microbiology·Kamyar MakvandiAla Habibian
Apr 4, 2015·PLoS Pathogens·Guoxin LiangMasamichi Muramatsu
Oct 16, 2016·Clinics in Liver Disease·Ryan M Kwok, Tram T Tran
Mar 17, 2018·Blood·Weicheng RenQiang Pan-Hammarström
Dec 17, 2015·World Journal of Gastroenterology : WJG·Mu-Hsien LeeHsiao-Wen Kao
Nov 15, 2019·Cell Transplantation·Ko-Chang HuangShinn-Zong Lin
Jun 9, 2015·World Journal of Hepatology·Shan GaoCarla S Coffin
Jul 26, 2012·Experimental Biology and Medicine·Laura VidalinoPatrizia Pontisso
May 18, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yanxin HuangYinghua Lan
Sep 2, 2016·São Paulo Medical Journal = Revista Paulista De Medicina·Mariana Nassif KerbauyJuliana Pereira
Nov 8, 2016·World Journal of Gastroenterology : WJG·Manoochehr Makvandi
Sep 14, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yan-Fang YeSu-Mei Cao
Jun 3, 2021·Diagnostics·Maria V KonoplevaAnatoly P Suslov
Apr 13, 2020·Best Practice & Research. Clinical Obstetrics & Gynaecology·Jennifer S M Mak, Terence T Lao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.